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Rational Design and In Vivo Characterization of mRNA-Encoded Broadly Neutralizing Antibody Combinations against HIV-1

Monoclonal antibodies have been used successfully as recombinant protein therapy; however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the mRNA-LNP platform for in vivo co-expression of 3 broadly neutralizing antibodies, PGDM1400, PGT121, and N6, directed against the...

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Detalles Bibliográficos
Autores principales:	Narayanan, Elisabeth, Falcone, Samantha, Elbashir, Sayda M., Attarwala, Husain, Hassett, Kimberly, Seaman, Michael S., Carfi, Andrea, Himansu, Sunny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680504/ https://www.ncbi.nlm.nih.gov/pubmed/36412833 http://dx.doi.org/10.3390/antib11040067

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