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Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method wa...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680523/ https://www.ncbi.nlm.nih.gov/pubmed/36412854 http://dx.doi.org/10.3390/jfb13040213 |
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author | Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. |
author_facet | Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. |
author_sort | Huang, Mengde |
collection | PubMed |
description | Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method was developed to segment coronary optical coherence tomography (OCT) images to obtain multilayer vessel geometries for biomechanical model construction. Intravascular OCT data were acquired from six patients (one male; mean age: 70.0) using a protocol approved by the local institutional review board with informed consent obtained. A total of 436 OCT slices were selected in this study. Manually segmented data were used as the gold standard for method development and validation. The edge detection method and cubic spline surface fitting were applied to detect and repair the internal elastic membrane (IEM), external elastic membrane (EEM) and adventitia–periadventitia interface (ADV). The mean errors of automatic contours compared to manually segmented contours were 1.40%, 4.34% and 6.97%, respectively. The single-layer mean plaque stress value from lumen was 117.91 kPa, 10.79% lower than that from three-layer models (132.33 kPa). On the adventitia, the single-layer mean plaque stress value was 50.46 kPa, 156.28% higher than that from three-layer models (19.74 kPa). The proposed segmentation technique may have wide applications in vulnerable plaque research. |
format | Online Article Text |
id | pubmed-9680523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96805232022-11-23 Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. J Funct Biomater Article Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method was developed to segment coronary optical coherence tomography (OCT) images to obtain multilayer vessel geometries for biomechanical model construction. Intravascular OCT data were acquired from six patients (one male; mean age: 70.0) using a protocol approved by the local institutional review board with informed consent obtained. A total of 436 OCT slices were selected in this study. Manually segmented data were used as the gold standard for method development and validation. The edge detection method and cubic spline surface fitting were applied to detect and repair the internal elastic membrane (IEM), external elastic membrane (EEM) and adventitia–periadventitia interface (ADV). The mean errors of automatic contours compared to manually segmented contours were 1.40%, 4.34% and 6.97%, respectively. The single-layer mean plaque stress value from lumen was 117.91 kPa, 10.79% lower than that from three-layer models (132.33 kPa). On the adventitia, the single-layer mean plaque stress value was 50.46 kPa, 156.28% higher than that from three-layer models (19.74 kPa). The proposed segmentation technique may have wide applications in vulnerable plaque research. MDPI 2022-11-02 /pmc/articles/PMC9680523/ /pubmed/36412854 http://dx.doi.org/10.3390/jfb13040213 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title | Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title_full | Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title_fullStr | Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title_full_unstemmed | Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title_short | Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations |
title_sort | human coronary plaque optical coherence tomography image repairing, multilayer segmentation and impact on plaque stress/strain calculations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680523/ https://www.ncbi.nlm.nih.gov/pubmed/36412854 http://dx.doi.org/10.3390/jfb13040213 |
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