Cargando…

Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations

Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method wa...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Mengde, Maehara, Akiko, Tang, Dalin, Zhu, Jian, Wang, Liang, Lv, Rui, Zhu, Yanwen, Zhang, Xiaoguo, Matsumura, Mitsuaki, Chen, Lijuan, Ma, Genshan, Mintz, Gary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680523/
https://www.ncbi.nlm.nih.gov/pubmed/36412854
http://dx.doi.org/10.3390/jfb13040213
_version_ 1784834438889209856
author Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
author_facet Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
author_sort Huang, Mengde
collection PubMed
description Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method was developed to segment coronary optical coherence tomography (OCT) images to obtain multilayer vessel geometries for biomechanical model construction. Intravascular OCT data were acquired from six patients (one male; mean age: 70.0) using a protocol approved by the local institutional review board with informed consent obtained. A total of 436 OCT slices were selected in this study. Manually segmented data were used as the gold standard for method development and validation. The edge detection method and cubic spline surface fitting were applied to detect and repair the internal elastic membrane (IEM), external elastic membrane (EEM) and adventitia–periadventitia interface (ADV). The mean errors of automatic contours compared to manually segmented contours were 1.40%, 4.34% and 6.97%, respectively. The single-layer mean plaque stress value from lumen was 117.91 kPa, 10.79% lower than that from three-layer models (132.33 kPa). On the adventitia, the single-layer mean plaque stress value was 50.46 kPa, 156.28% higher than that from three-layer models (19.74 kPa). The proposed segmentation technique may have wide applications in vulnerable plaque research.
format Online
Article
Text
id pubmed-9680523
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96805232022-11-23 Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations Huang, Mengde Maehara, Akiko Tang, Dalin Zhu, Jian Wang, Liang Lv, Rui Zhu, Yanwen Zhang, Xiaoguo Matsumura, Mitsuaki Chen, Lijuan Ma, Genshan Mintz, Gary S. J Funct Biomater Article Coronary vessel layer structure may have a considerable impact on plaque stress/strain calculations. Most current plaque models use single-layer vessel structures due to the lack of available multilayer segmentation techniques. In this paper, an automatic multilayer segmentation and repair method was developed to segment coronary optical coherence tomography (OCT) images to obtain multilayer vessel geometries for biomechanical model construction. Intravascular OCT data were acquired from six patients (one male; mean age: 70.0) using a protocol approved by the local institutional review board with informed consent obtained. A total of 436 OCT slices were selected in this study. Manually segmented data were used as the gold standard for method development and validation. The edge detection method and cubic spline surface fitting were applied to detect and repair the internal elastic membrane (IEM), external elastic membrane (EEM) and adventitia–periadventitia interface (ADV). The mean errors of automatic contours compared to manually segmented contours were 1.40%, 4.34% and 6.97%, respectively. The single-layer mean plaque stress value from lumen was 117.91 kPa, 10.79% lower than that from three-layer models (132.33 kPa). On the adventitia, the single-layer mean plaque stress value was 50.46 kPa, 156.28% higher than that from three-layer models (19.74 kPa). The proposed segmentation technique may have wide applications in vulnerable plaque research. MDPI 2022-11-02 /pmc/articles/PMC9680523/ /pubmed/36412854 http://dx.doi.org/10.3390/jfb13040213 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Mengde
Maehara, Akiko
Tang, Dalin
Zhu, Jian
Wang, Liang
Lv, Rui
Zhu, Yanwen
Zhang, Xiaoguo
Matsumura, Mitsuaki
Chen, Lijuan
Ma, Genshan
Mintz, Gary S.
Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title_full Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title_fullStr Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title_full_unstemmed Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title_short Human Coronary Plaque Optical Coherence Tomography Image Repairing, Multilayer Segmentation and Impact on Plaque Stress/Strain Calculations
title_sort human coronary plaque optical coherence tomography image repairing, multilayer segmentation and impact on plaque stress/strain calculations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680523/
https://www.ncbi.nlm.nih.gov/pubmed/36412854
http://dx.doi.org/10.3390/jfb13040213
work_keys_str_mv AT huangmengde humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT maeharaakiko humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT tangdalin humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT zhujian humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT wangliang humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT lvrui humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT zhuyanwen humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT zhangxiaoguo humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT matsumuramitsuaki humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT chenlijuan humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT magenshan humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations
AT mintzgarys humancoronaryplaqueopticalcoherencetomographyimagerepairingmultilayersegmentationandimpactonplaquestressstraincalculations