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Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders
INTRODUCTION: Pseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) indi...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680558/ https://www.ncbi.nlm.nih.gov/pubmed/36425476 http://dx.doi.org/10.3389/fnins.2022.1045585 |
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author | Ye, Fang Du, Lei Liu, Bing Gao, Xinying Yang, Aocai Liu, Die Chen, Yue Lv, Kuan Xu, Pengfei Chen, Yuanmei Liu, Jing Zhang, Lipeng Li, Shijun Shmuel, Amir Zhang, Qi Ma, Guolin |
author_facet | Ye, Fang Du, Lei Liu, Bing Gao, Xinying Yang, Aocai Liu, Die Chen, Yue Lv, Kuan Xu, Pengfei Chen, Yuanmei Liu, Jing Zhang, Lipeng Li, Shijun Shmuel, Amir Zhang, Qi Ma, Guolin |
author_sort | Ye, Fang |
collection | PubMed |
description | INTRODUCTION: Pseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) individuals with their age-matched typically developing (TD) children using pCASL perfusion imaging. MATERIALS AND METHODS: This cross-sectional study enrolled 17 individuals with ASD and 13 TD children. All participants underwent pCASL examination on a 3.0 T MRI scanner. Children in two groups were assessed for clinical characteristics and developmental profiles using Autism Behavior Checklist (ABC) and Gesell development diagnosis scale (GDDS), respectively. We compared CBF in different cerebral regions of ASD and TD children. We also assessed the association between CBF and clinical characteristics/developmental profile. RESULTS: Compared with TD children, individuals with ASD demonstrated a reduction in CBF in the left frontal lobe, the bilateral parietal lobes, and the bilateral temporal lobes. Within the ASD group, CBF was significantly higher in the right parietal lobe than in the left side. Correlation analysis of behavior characteristics and CBF in different regions showed a positive correlation between body and object domain scores on the ABC and CBF of the bilateral occipital lobes, and separately, between language domain scores and CBF of the left frontal lobe. The score of the social and self-help domain was negatively correlated with the CBF of the left frontal lobe, the left parietal lobe, and the left temporal lobe. CONCLUSION: Cerebral blood flow was found to be negatively correlated with scores in the social and self-help domain, and positively correlated with those in the body and object domain, indicating that CBF values are a potential MRI-based biomarker of disease severity in ASD patients. The findings may provide novel insight into the pathophysiological mechanisms of ASD. |
format | Online Article Text |
id | pubmed-9680558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96805582022-11-23 Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders Ye, Fang Du, Lei Liu, Bing Gao, Xinying Yang, Aocai Liu, Die Chen, Yue Lv, Kuan Xu, Pengfei Chen, Yuanmei Liu, Jing Zhang, Lipeng Li, Shijun Shmuel, Amir Zhang, Qi Ma, Guolin Front Neurosci Neuroscience INTRODUCTION: Pseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) individuals with their age-matched typically developing (TD) children using pCASL perfusion imaging. MATERIALS AND METHODS: This cross-sectional study enrolled 17 individuals with ASD and 13 TD children. All participants underwent pCASL examination on a 3.0 T MRI scanner. Children in two groups were assessed for clinical characteristics and developmental profiles using Autism Behavior Checklist (ABC) and Gesell development diagnosis scale (GDDS), respectively. We compared CBF in different cerebral regions of ASD and TD children. We also assessed the association between CBF and clinical characteristics/developmental profile. RESULTS: Compared with TD children, individuals with ASD demonstrated a reduction in CBF in the left frontal lobe, the bilateral parietal lobes, and the bilateral temporal lobes. Within the ASD group, CBF was significantly higher in the right parietal lobe than in the left side. Correlation analysis of behavior characteristics and CBF in different regions showed a positive correlation between body and object domain scores on the ABC and CBF of the bilateral occipital lobes, and separately, between language domain scores and CBF of the left frontal lobe. The score of the social and self-help domain was negatively correlated with the CBF of the left frontal lobe, the left parietal lobe, and the left temporal lobe. CONCLUSION: Cerebral blood flow was found to be negatively correlated with scores in the social and self-help domain, and positively correlated with those in the body and object domain, indicating that CBF values are a potential MRI-based biomarker of disease severity in ASD patients. The findings may provide novel insight into the pathophysiological mechanisms of ASD. Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9680558/ /pubmed/36425476 http://dx.doi.org/10.3389/fnins.2022.1045585 Text en Copyright © 2022 Ye, Du, Liu, Gao, Yang, Liu, Chen, Lv, Xu, Chen, Liu, Zhang, Li, Shmuel, Zhang and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ye, Fang Du, Lei Liu, Bing Gao, Xinying Yang, Aocai Liu, Die Chen, Yue Lv, Kuan Xu, Pengfei Chen, Yuanmei Liu, Jing Zhang, Lipeng Li, Shijun Shmuel, Amir Zhang, Qi Ma, Guolin Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title_full | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title_fullStr | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title_full_unstemmed | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title_short | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
title_sort | application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680558/ https://www.ncbi.nlm.nih.gov/pubmed/36425476 http://dx.doi.org/10.3389/fnins.2022.1045585 |
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