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Tag-free, specific conjugation of glycosylated IgG1 antibodies using microbial transglutaminase
We present an efficient approach for tag-free, site-specific conjugation of a fully glycosylated antibody using microbial transglutaminase (mTG). We created variants of trastuzumab where a single surface-exposed residue of the human crystallizable fragment had been substituted to glutamine, with the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680618/ https://www.ncbi.nlm.nih.gov/pubmed/36505706 http://dx.doi.org/10.1039/d2ra05630e |