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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggested that the size of nanostructural constraints and mechanic...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680735/ https://www.ncbi.nlm.nih.gov/pubmed/36425310 http://dx.doi.org/10.1016/j.bpr.2021.100006 |
| _version_ | 1784834476527845376 |
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| author | Kim, Jichul |
| author_facet | Kim, Jichul |
| author_sort | Kim, Jichul |
| collection | PubMed |
| description | Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggested that the size of nanostructural constraints and mechanical pulling applied on lipid membranes affect the generation of cellular traction forces and signaling transduction at focal adhesions. This work provides predictions on how lipid membranes contribute to mechanotransduction at cellular focal adhesions. |
| format | Online Article Text |
| id | pubmed-9680735 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96807352022-11-23 A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes Kim, Jichul Biophys Rep (N Y) Article Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions. Calculations suggested that the size of nanostructural constraints and mechanical pulling applied on lipid membranes affect the generation of cellular traction forces and signaling transduction at focal adhesions. This work provides predictions on how lipid membranes contribute to mechanotransduction at cellular focal adhesions. Elsevier 2021-07-21 /pmc/articles/PMC9680735/ /pubmed/36425310 http://dx.doi.org/10.1016/j.bpr.2021.100006 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Kim, Jichul A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title | A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title_full | A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title_fullStr | A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title_full_unstemmed | A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title_short | A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| title_sort | possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680735/ https://www.ncbi.nlm.nih.gov/pubmed/36425310 http://dx.doi.org/10.1016/j.bpr.2021.100006 |
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