Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

PURPOSE: To investigate induction of cell death in Osteosarcoma (OS) using the anti-tuberculosis drug, rifampicin, loaded into exosomes. PATIENTS AND METHODS: BMSC-exosomes were isolated by ultracentrifugation and loaded ultrasonically with rifampicin. Nanoparticle exosome-rifampicin (EXO-RIF) was a...

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Detalles Bibliográficos
Autores principales: Chen, Wenkai, Lin, Wenping, Yu, Naichun, Zhang, Linlin, Wu, Zuoxing, Chen, Yongjie, Li, Zongguang, Gong, Fengqing, Li, Na, Chen, Xiaohui, He, Xu, Wu, Yue, Zeng, Xiangchen, Yueh, Yuting, Xu, Ren, Ji, Guangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680970/
https://www.ncbi.nlm.nih.gov/pubmed/36426375
http://dx.doi.org/10.2147/IJN.S379917

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