Cargando…
Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was de...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Penerbit Universiti Sains Malaysia
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681004/ https://www.ncbi.nlm.nih.gov/pubmed/36474531 http://dx.doi.org/10.21315/mjms2022.29.5.3 |
_version_ | 1784834525564502016 |
---|---|
author | Al-Ani, Ahmad Habeeb Hattab Dala Ali Othman, Noordin Hassali, Mohamed Azmi Ibrahim, Baharudin |
author_facet | Al-Ani, Ahmad Habeeb Hattab Dala Ali Othman, Noordin Hassali, Mohamed Azmi Ibrahim, Baharudin |
author_sort | Al-Ani, Ahmad Habeeb Hattab Dala Ali |
collection | PubMed |
description | Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was designed to summarise the available evidences regarding the adequacy of the empiric antimicrobial therapy (EAMT), its predictors and its impact on the outcomes in intensive care unit (ICU) sepsis patients. Providing an adequate EAMT is considered one of the cornerstones of sepsis management as it has been found to be associated with better survival and is a good predictor for shorter ICU-length-of-stay. In contrast, inadequate EAMT in sepsis patients is associated with poor clinical outcomes including increased mortality and prolonged hospital stay. Evidence from this review suggest that it is important to identify determinants of inadequate EAMT to optimise the antimicrobial therapy provided to sepsis patients. Predictors of inadequate EAMT included co-morbidities (cancer), source and type of infection, higher Acute Physiology and Chronic Health Evaluation (APACHI-II) score and long hospital stay prior to the infection. As EAMT is considered as one of the effective treatment strategies to prevent sepsis associated death, healthcare providers should ensure the adequate antimicrobial therapy is provided for sepsis patients to improve and optimise their management. |
format | Online Article Text |
id | pubmed-9681004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Penerbit Universiti Sains Malaysia |
record_format | MEDLINE/PubMed |
spelling | pubmed-96810042022-12-05 Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review Al-Ani, Ahmad Habeeb Hattab Dala Ali Othman, Noordin Hassali, Mohamed Azmi Ibrahim, Baharudin Malays J Med Sci Review Article Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was designed to summarise the available evidences regarding the adequacy of the empiric antimicrobial therapy (EAMT), its predictors and its impact on the outcomes in intensive care unit (ICU) sepsis patients. Providing an adequate EAMT is considered one of the cornerstones of sepsis management as it has been found to be associated with better survival and is a good predictor for shorter ICU-length-of-stay. In contrast, inadequate EAMT in sepsis patients is associated with poor clinical outcomes including increased mortality and prolonged hospital stay. Evidence from this review suggest that it is important to identify determinants of inadequate EAMT to optimise the antimicrobial therapy provided to sepsis patients. Predictors of inadequate EAMT included co-morbidities (cancer), source and type of infection, higher Acute Physiology and Chronic Health Evaluation (APACHI-II) score and long hospital stay prior to the infection. As EAMT is considered as one of the effective treatment strategies to prevent sepsis associated death, healthcare providers should ensure the adequate antimicrobial therapy is provided for sepsis patients to improve and optimise their management. Penerbit Universiti Sains Malaysia 2022-10 2022-10-28 /pmc/articles/PMC9681004/ /pubmed/36474531 http://dx.doi.org/10.21315/mjms2022.29.5.3 Text en © Penerbit Universiti Sains Malaysia, 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Article Al-Ani, Ahmad Habeeb Hattab Dala Ali Othman, Noordin Hassali, Mohamed Azmi Ibrahim, Baharudin Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title | Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title_full | Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title_fullStr | Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title_full_unstemmed | Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title_short | Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review |
title_sort | adequacy of empiric antibiotics therapy and its impact on outcomes in adult critically ill sepsis patients: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681004/ https://www.ncbi.nlm.nih.gov/pubmed/36474531 http://dx.doi.org/10.21315/mjms2022.29.5.3 |
work_keys_str_mv | AT alaniahmadhabeebhattabdalaali adequacyofempiricantibioticstherapyanditsimpactonoutcomesinadultcriticallyillsepsispatientsareview AT othmannoordin adequacyofempiricantibioticstherapyanditsimpactonoutcomesinadultcriticallyillsepsispatientsareview AT hassalimohamedazmi adequacyofempiricantibioticstherapyanditsimpactonoutcomesinadultcriticallyillsepsispatientsareview AT ibrahimbaharudin adequacyofempiricantibioticstherapyanditsimpactonoutcomesinadultcriticallyillsepsispatientsareview |