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Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review

Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was de...

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Autores principales: Al-Ani, Ahmad Habeeb Hattab Dala Ali, Othman, Noordin, Hassali, Mohamed Azmi, Ibrahim, Baharudin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681004/
https://www.ncbi.nlm.nih.gov/pubmed/36474531
http://dx.doi.org/10.21315/mjms2022.29.5.3
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author Al-Ani, Ahmad Habeeb Hattab Dala Ali
Othman, Noordin
Hassali, Mohamed Azmi
Ibrahim, Baharudin
author_facet Al-Ani, Ahmad Habeeb Hattab Dala Ali
Othman, Noordin
Hassali, Mohamed Azmi
Ibrahim, Baharudin
author_sort Al-Ani, Ahmad Habeeb Hattab Dala Ali
collection PubMed
description Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was designed to summarise the available evidences regarding the adequacy of the empiric antimicrobial therapy (EAMT), its predictors and its impact on the outcomes in intensive care unit (ICU) sepsis patients. Providing an adequate EAMT is considered one of the cornerstones of sepsis management as it has been found to be associated with better survival and is a good predictor for shorter ICU-length-of-stay. In contrast, inadequate EAMT in sepsis patients is associated with poor clinical outcomes including increased mortality and prolonged hospital stay. Evidence from this review suggest that it is important to identify determinants of inadequate EAMT to optimise the antimicrobial therapy provided to sepsis patients. Predictors of inadequate EAMT included co-morbidities (cancer), source and type of infection, higher Acute Physiology and Chronic Health Evaluation (APACHI-II) score and long hospital stay prior to the infection. As EAMT is considered as one of the effective treatment strategies to prevent sepsis associated death, healthcare providers should ensure the adequate antimicrobial therapy is provided for sepsis patients to improve and optimise their management.
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spelling pubmed-96810042022-12-05 Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review Al-Ani, Ahmad Habeeb Hattab Dala Ali Othman, Noordin Hassali, Mohamed Azmi Ibrahim, Baharudin Malays J Med Sci Review Article Sepsis is a medical emergency that involves a systemic immunological response due to an infection, resulting in the end-stage-organs malfunction and death. It is associated with high mortality rate despite a better understanding of the disease pathology and the mechanism involved. This review was designed to summarise the available evidences regarding the adequacy of the empiric antimicrobial therapy (EAMT), its predictors and its impact on the outcomes in intensive care unit (ICU) sepsis patients. Providing an adequate EAMT is considered one of the cornerstones of sepsis management as it has been found to be associated with better survival and is a good predictor for shorter ICU-length-of-stay. In contrast, inadequate EAMT in sepsis patients is associated with poor clinical outcomes including increased mortality and prolonged hospital stay. Evidence from this review suggest that it is important to identify determinants of inadequate EAMT to optimise the antimicrobial therapy provided to sepsis patients. Predictors of inadequate EAMT included co-morbidities (cancer), source and type of infection, higher Acute Physiology and Chronic Health Evaluation (APACHI-II) score and long hospital stay prior to the infection. As EAMT is considered as one of the effective treatment strategies to prevent sepsis associated death, healthcare providers should ensure the adequate antimicrobial therapy is provided for sepsis patients to improve and optimise their management. Penerbit Universiti Sains Malaysia 2022-10 2022-10-28 /pmc/articles/PMC9681004/ /pubmed/36474531 http://dx.doi.org/10.21315/mjms2022.29.5.3 Text en © Penerbit Universiti Sains Malaysia, 2022 https://creativecommons.org/licenses/by/4.0/This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review Article
Al-Ani, Ahmad Habeeb Hattab Dala Ali
Othman, Noordin
Hassali, Mohamed Azmi
Ibrahim, Baharudin
Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title_full Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title_fullStr Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title_full_unstemmed Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title_short Adequacy of Empiric Antibiotics Therapy and Its Impact on Outcomes in Adult Critically Ill Sepsis Patients: A Review
title_sort adequacy of empiric antibiotics therapy and its impact on outcomes in adult critically ill sepsis patients: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681004/
https://www.ncbi.nlm.nih.gov/pubmed/36474531
http://dx.doi.org/10.21315/mjms2022.29.5.3
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