Screening of Selected Stingless Bee Honey Varieties for ACE2-Spike Protein-Binding Inhibition Activity: A Potential Preventive Medicine Against SARS-Cov-2 Infection

The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 sample...

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Detalles Bibliográficos
Autores principales: Arung, Enos Tangke, Ramadhan, Rico, Mandzilkh, Liidza Diana, Santoso, Prasetia Aktavinaldy, Matsumoto, Masako, Nagata, Maki, Kusuma, Irawan Wijaya, Paramita, Swandari, Sukemi, Yadi, Takemoto, Naomichi, Amen, Yhiya, Syafrizal, Shimizu, Kuniyoshi, Tandirogang, Nataniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681006/
https://www.ncbi.nlm.nih.gov/pubmed/36474534
http://dx.doi.org/10.21315/mjms2022.29.5.15
Descripción
Sumario:The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.

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