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A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells

A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfu...

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Autores principales: Strandmark, Julia, Darboe, Alansana, Diray-Arce, Joann, Ben-Othman, Rym, Vignolo, Sofia M., Rao, Shun, Smolen, Kinga K., Leroux-Roels, Geert, Idoko, Olubukola T., Sanchez-Schmitz, Guzmán, Ozonoff, Al, Levy, Ofer, Kollmann, Tobias R., Marchant, Arnaud, Kampmann, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681035/
https://www.ncbi.nlm.nih.gov/pubmed/36426360
http://dx.doi.org/10.3389/fimmu.2022.1043375
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author Strandmark, Julia
Darboe, Alansana
Diray-Arce, Joann
Ben-Othman, Rym
Vignolo, Sofia M.
Rao, Shun
Smolen, Kinga K.
Leroux-Roels, Geert
Idoko, Olubukola T.
Sanchez-Schmitz, Guzmán
Ozonoff, Al
Levy, Ofer
Kollmann, Tobias R.
Marchant, Arnaud
Kampmann, Beate
author_facet Strandmark, Julia
Darboe, Alansana
Diray-Arce, Joann
Ben-Othman, Rym
Vignolo, Sofia M.
Rao, Shun
Smolen, Kinga K.
Leroux-Roels, Geert
Idoko, Olubukola T.
Sanchez-Schmitz, Guzmán
Ozonoff, Al
Levy, Ofer
Kollmann, Tobias R.
Marchant, Arnaud
Kampmann, Beate
author_sort Strandmark, Julia
collection PubMed
description A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4(+) T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4(+) T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154(+)IL-2(+)TNFα(+) CD4(+) T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells
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spelling pubmed-96810352022-11-23 A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells Strandmark, Julia Darboe, Alansana Diray-Arce, Joann Ben-Othman, Rym Vignolo, Sofia M. Rao, Shun Smolen, Kinga K. Leroux-Roels, Geert Idoko, Olubukola T. Sanchez-Schmitz, Guzmán Ozonoff, Al Levy, Ofer Kollmann, Tobias R. Marchant, Arnaud Kampmann, Beate Front Immunol Immunology A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4(+) T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4(+) T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154(+)IL-2(+)TNFα(+) CD4(+) T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9681035/ /pubmed/36426360 http://dx.doi.org/10.3389/fimmu.2022.1043375 Text en Copyright © 2022 Strandmark, Darboe, Diray-Arce, Ben-Othman, Vignolo, Rao, Smolen, Leroux-Roels, Idoko, Sanchez-Schmitz, Ozonoff, Levy, Kollmann, Marchant and Kampmann https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Strandmark, Julia
Darboe, Alansana
Diray-Arce, Joann
Ben-Othman, Rym
Vignolo, Sofia M.
Rao, Shun
Smolen, Kinga K.
Leroux-Roels, Geert
Idoko, Olubukola T.
Sanchez-Schmitz, Guzmán
Ozonoff, Al
Levy, Ofer
Kollmann, Tobias R.
Marchant, Arnaud
Kampmann, Beate
A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title_full A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title_fullStr A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title_full_unstemmed A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title_short A single birth dose of Hepatitis B vaccine induces polyfunctional CD4(+) T helper cells
title_sort single birth dose of hepatitis b vaccine induces polyfunctional cd4(+) t helper cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681035/
https://www.ncbi.nlm.nih.gov/pubmed/36426360
http://dx.doi.org/10.3389/fimmu.2022.1043375
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