Rad regulation of Ca(V)1.2 channels controls cardiac fight-or-flight response

Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart’s innate contractile reserve. We show that four protein kinase A (PKA)-phosphorylated residues in Rad, a calcium channel i...

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Detalles Bibliográficos
Autores principales: Papa, Arianne, Zakharov, Sergey I., Katchman, Alexander N., Kushner, Jared S., Chen, Bi-xing, Yang, Lin, Liu, Guoxia, Jimenez, Alejandro Sanchez, Eisert, Robyn J., Bradshaw, Gary A., Dun, Wen, Ali, Shah R., Rodriques, Aaron, Zhou, Karen, Topkara, Veli, Yang, Mu, Morrow, John P., Tsai, Emily J., Karlin, Arthur, Wan, Elaine, Kalocsay, Marian, Pitt, Geoffrey S., Colecraft, Henry M., Ben-Johny, Manu, Marx, Steven O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681059/
https://www.ncbi.nlm.nih.gov/pubmed/36424916
http://dx.doi.org/10.1038/s44161-022-00157-y

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