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Cancer metastasis is related to normal tissue stemness

The occurrence of cancer metastasis may be related to stem cells in normal tissues. We searched for patient IDs with both normal tissue stem cell values and TCGA (The Cancer Genome Atlas) clinical data for pairing and obtained 639 sets of data (stemness index of normal tissue, stemness index of tumo...

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Detalles Bibliográficos
Autores principales: Peng, Xing Yue, Dong, Bocun, Liu, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681098/
https://www.ncbi.nlm.nih.gov/pubmed/36413554
http://dx.doi.org/10.1371/journal.pone.0277811
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author Peng, Xing Yue
Dong, Bocun
Liu, Xiaohui
author_facet Peng, Xing Yue
Dong, Bocun
Liu, Xiaohui
author_sort Peng, Xing Yue
collection PubMed
description The occurrence of cancer metastasis may be related to stem cells in normal tissues. We searched for patient IDs with both normal tissue stem cell values and TCGA (The Cancer Genome Atlas) clinical data for pairing and obtained 639 sets of data (stemness index of normal tissue, stemness index of tumor tissue, cancer stage, distant metastasis, tumor size) and invasion, and lymph node involvement). However, clinical data on cancer metastasis are of only four stages (e.g., Stage I, II, III, and IV), which cannot show subtle changes continuously. We need to find an effective data mining method to transform this four-valued clinical description into a numerical curve. We data-mine this data through numericalization, sorting, and noise reduction filtering. The results showed that: as the normal tissue stemness value (NS) increased, the tumor tissue stemness value (TS) increased proportionally (1.26 times NS). When NS >0.5, the rate of change in TS decelerated (0.43 times NS), and tumor metastasis began to occur. Clinical indicators, such as cancer stage, distant metastasis, tumor size and invasion, and lymph node involvement, showed that tumor metastasis became more and more severe with the increase of NS. This study suggests that tumor metastasis is triggered when the NS in the patient’s body is more significant than 0.5.
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spelling pubmed-96810982022-11-23 Cancer metastasis is related to normal tissue stemness Peng, Xing Yue Dong, Bocun Liu, Xiaohui PLoS One Research Article The occurrence of cancer metastasis may be related to stem cells in normal tissues. We searched for patient IDs with both normal tissue stem cell values and TCGA (The Cancer Genome Atlas) clinical data for pairing and obtained 639 sets of data (stemness index of normal tissue, stemness index of tumor tissue, cancer stage, distant metastasis, tumor size) and invasion, and lymph node involvement). However, clinical data on cancer metastasis are of only four stages (e.g., Stage I, II, III, and IV), which cannot show subtle changes continuously. We need to find an effective data mining method to transform this four-valued clinical description into a numerical curve. We data-mine this data through numericalization, sorting, and noise reduction filtering. The results showed that: as the normal tissue stemness value (NS) increased, the tumor tissue stemness value (TS) increased proportionally (1.26 times NS). When NS >0.5, the rate of change in TS decelerated (0.43 times NS), and tumor metastasis began to occur. Clinical indicators, such as cancer stage, distant metastasis, tumor size and invasion, and lymph node involvement, showed that tumor metastasis became more and more severe with the increase of NS. This study suggests that tumor metastasis is triggered when the NS in the patient’s body is more significant than 0.5. Public Library of Science 2022-11-22 /pmc/articles/PMC9681098/ /pubmed/36413554 http://dx.doi.org/10.1371/journal.pone.0277811 Text en © 2022 Peng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peng, Xing Yue
Dong, Bocun
Liu, Xiaohui
Cancer metastasis is related to normal tissue stemness
title Cancer metastasis is related to normal tissue stemness
title_full Cancer metastasis is related to normal tissue stemness
title_fullStr Cancer metastasis is related to normal tissue stemness
title_full_unstemmed Cancer metastasis is related to normal tissue stemness
title_short Cancer metastasis is related to normal tissue stemness
title_sort cancer metastasis is related to normal tissue stemness
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681098/
https://www.ncbi.nlm.nih.gov/pubmed/36413554
http://dx.doi.org/10.1371/journal.pone.0277811
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