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Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

BACKGROUND: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptionally silences either the maternal or paternal X in e...

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Detalles Bibliográficos
Autores principales:	Roberts, Amy L, Morea, Alessandro, Amar, Ariella, Zito, Antonino, El-Sayed Moustafa, Julia S, Tomlinson, Max, Bowyer, Ruth CE, Zhang, Xinyuan, Christiansen, Colette, Costeira, Ricardo, Steves, Claire J, Mangino, Massimo, Bell, Jordana T, Wong, Chloe CY, Vyse, Timothy J, Small, Kerrin S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Epidemiology and Global Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681199/ https://www.ncbi.nlm.nih.gov/pubmed/36412098 http://dx.doi.org/10.7554/eLife.78263

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