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Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD), in a few decades, is expected to be the commonest cause of end-stage liver disease and liver cancer surpassing all other etiologies. Urbanization and modern lifestyle have led to global epidemic of NAFLD with alarming prevalence rates across the globe. Its m...

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Autores principales: Shrestha, Ananta, Pradhananga, Shrijana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681569/
https://www.ncbi.nlm.nih.gov/pubmed/36466101
http://dx.doi.org/10.5005/jp-journals-10018-1359
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author Shrestha, Ananta
Pradhananga, Shrijana
author_facet Shrestha, Ananta
Pradhananga, Shrijana
author_sort Shrestha, Ananta
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD), in a few decades, is expected to be the commonest cause of end-stage liver disease and liver cancer surpassing all other etiologies. Urbanization and modern lifestyle have led to global epidemic of NAFLD with alarming prevalence rates across the globe. Its multisystemic involvement manifests as metabolic syndrome, diabetes, cardiovascular disease, end-stage liver disease, and hepatic and extrahepatic malignancies. The absence of promising therapy for halting disease progression in NAFLD is a challenge that is not only limited to liver disease but also other organs involved. It is unrealistic to expect any significant impact of pharmacotherapies in overall survival of NAFLD patients, given that the morbidity and mortality in these patients are contributed by conditions other than that of liver. Liver-centric approach in managing NAFLD will be futile unless the problem is dealt in a holistic manner. Lifestyle modifications have been repeatedly appraised in prevention and treatment of various diseases linked to metabolic syndrome including NAFLD. Despite being inexpensive and highly efficacious in prevention and treatment of different manifestations of NAFLD, lifestyle intervention often fails to gather sufficient interest among patients and physicians alike. This review intends to highlight pleiotropic nature of this disease, limitations of currently available pharmacotherapies and evidence that emphasizing lifestyle intervention is the only way to holistically deal in patients with NAFLD. HOW TO CITE THIS ARTICLE: Shrestha A, Pradhananga S. Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2022;12(Suppl 1):S51–S58.
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spelling pubmed-96815692022-12-02 Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease Shrestha, Ananta Pradhananga, Shrijana Euroasian J Hepatogastroenterol Review Article Nonalcoholic fatty liver disease (NAFLD), in a few decades, is expected to be the commonest cause of end-stage liver disease and liver cancer surpassing all other etiologies. Urbanization and modern lifestyle have led to global epidemic of NAFLD with alarming prevalence rates across the globe. Its multisystemic involvement manifests as metabolic syndrome, diabetes, cardiovascular disease, end-stage liver disease, and hepatic and extrahepatic malignancies. The absence of promising therapy for halting disease progression in NAFLD is a challenge that is not only limited to liver disease but also other organs involved. It is unrealistic to expect any significant impact of pharmacotherapies in overall survival of NAFLD patients, given that the morbidity and mortality in these patients are contributed by conditions other than that of liver. Liver-centric approach in managing NAFLD will be futile unless the problem is dealt in a holistic manner. Lifestyle modifications have been repeatedly appraised in prevention and treatment of various diseases linked to metabolic syndrome including NAFLD. Despite being inexpensive and highly efficacious in prevention and treatment of different manifestations of NAFLD, lifestyle intervention often fails to gather sufficient interest among patients and physicians alike. This review intends to highlight pleiotropic nature of this disease, limitations of currently available pharmacotherapies and evidence that emphasizing lifestyle intervention is the only way to holistically deal in patients with NAFLD. HOW TO CITE THIS ARTICLE: Shrestha A, Pradhananga S. Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2022;12(Suppl 1):S51–S58. Jaypee Brothers Medical Publishers 2022-07 /pmc/articles/PMC9681569/ /pubmed/36466101 http://dx.doi.org/10.5005/jp-journals-10018-1359 Text en Copyright © 2022; Jaypee Brothers Medical Publishers (P) Ltd. https://creativecommons.org/licenses/by-nc/4.0/© The Author(s). 2022 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review Article
Shrestha, Ananta
Pradhananga, Shrijana
Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title_full Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title_fullStr Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title_full_unstemmed Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title_short Holistic Approach in the Management of Nonalcoholic Fatty Liver Disease
title_sort holistic approach in the management of nonalcoholic fatty liver disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681569/
https://www.ncbi.nlm.nih.gov/pubmed/36466101
http://dx.doi.org/10.5005/jp-journals-10018-1359
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