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Gestationally dependent immune organization at the maternal-fetal interface

The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell f...

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Detalles Bibliográficos
Autores principales: Moore, Amber R., Vivanco Gonzalez, Nora, Plummer, Katherine A., Mitchel, Olivia R., Kaur, Harleen, Rivera, Moises, Collica, Brian, Goldston, Mako, Filiz, Ferda, Angelo, Michael, Palmer, Theo D., Bendall, Sean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681661/
https://www.ncbi.nlm.nih.gov/pubmed/36384130
http://dx.doi.org/10.1016/j.celrep.2022.111651
Descripción
Sumario:The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell framework to simultaneously immuno-phenotype circulating, endovascular, and tissue-resident cells at the maternal-fetal interface throughout gestation, discriminating maternal and fetal contributions. Our data reveal distinct immune profiles across the endovascular and tissue compartments with tractable dynamics throughout gestation that respond to a systemic immune challenge in a gestationally dependent manner. We uncover a significant role for the innate immune system where phagocytes and neutrophils drive temporal organization of the placenta through remarkably diverse populations, including PD-L1(+) subsets having compartmental and early gestational bias. Our approach and accompanying datasets provide a resource for additional investigations into gestational immunology and evoke a more significant role for the innate immune system in establishing the microenvironment of early pregnancy.