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Gestationally dependent immune organization at the maternal-fetal interface
The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell f...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681661/ https://www.ncbi.nlm.nih.gov/pubmed/36384130 http://dx.doi.org/10.1016/j.celrep.2022.111651 |
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author | Moore, Amber R. Vivanco Gonzalez, Nora Plummer, Katherine A. Mitchel, Olivia R. Kaur, Harleen Rivera, Moises Collica, Brian Goldston, Mako Filiz, Ferda Angelo, Michael Palmer, Theo D. Bendall, Sean C. |
author_facet | Moore, Amber R. Vivanco Gonzalez, Nora Plummer, Katherine A. Mitchel, Olivia R. Kaur, Harleen Rivera, Moises Collica, Brian Goldston, Mako Filiz, Ferda Angelo, Michael Palmer, Theo D. Bendall, Sean C. |
author_sort | Moore, Amber R. |
collection | PubMed |
description | The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell framework to simultaneously immuno-phenotype circulating, endovascular, and tissue-resident cells at the maternal-fetal interface throughout gestation, discriminating maternal and fetal contributions. Our data reveal distinct immune profiles across the endovascular and tissue compartments with tractable dynamics throughout gestation that respond to a systemic immune challenge in a gestationally dependent manner. We uncover a significant role for the innate immune system where phagocytes and neutrophils drive temporal organization of the placenta through remarkably diverse populations, including PD-L1(+) subsets having compartmental and early gestational bias. Our approach and accompanying datasets provide a resource for additional investigations into gestational immunology and evoke a more significant role for the innate immune system in establishing the microenvironment of early pregnancy. |
format | Online Article Text |
id | pubmed-9681661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-96816612022-11-25 Gestationally dependent immune organization at the maternal-fetal interface Moore, Amber R. Vivanco Gonzalez, Nora Plummer, Katherine A. Mitchel, Olivia R. Kaur, Harleen Rivera, Moises Collica, Brian Goldston, Mako Filiz, Ferda Angelo, Michael Palmer, Theo D. Bendall, Sean C. Cell Rep Resource The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell framework to simultaneously immuno-phenotype circulating, endovascular, and tissue-resident cells at the maternal-fetal interface throughout gestation, discriminating maternal and fetal contributions. Our data reveal distinct immune profiles across the endovascular and tissue compartments with tractable dynamics throughout gestation that respond to a systemic immune challenge in a gestationally dependent manner. We uncover a significant role for the innate immune system where phagocytes and neutrophils drive temporal organization of the placenta through remarkably diverse populations, including PD-L1(+) subsets having compartmental and early gestational bias. Our approach and accompanying datasets provide a resource for additional investigations into gestational immunology and evoke a more significant role for the innate immune system in establishing the microenvironment of early pregnancy. Cell Press 2022-11-15 /pmc/articles/PMC9681661/ /pubmed/36384130 http://dx.doi.org/10.1016/j.celrep.2022.111651 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Resource Moore, Amber R. Vivanco Gonzalez, Nora Plummer, Katherine A. Mitchel, Olivia R. Kaur, Harleen Rivera, Moises Collica, Brian Goldston, Mako Filiz, Ferda Angelo, Michael Palmer, Theo D. Bendall, Sean C. Gestationally dependent immune organization at the maternal-fetal interface |
title | Gestationally dependent immune organization at the maternal-fetal interface |
title_full | Gestationally dependent immune organization at the maternal-fetal interface |
title_fullStr | Gestationally dependent immune organization at the maternal-fetal interface |
title_full_unstemmed | Gestationally dependent immune organization at the maternal-fetal interface |
title_short | Gestationally dependent immune organization at the maternal-fetal interface |
title_sort | gestationally dependent immune organization at the maternal-fetal interface |
topic | Resource |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681661/ https://www.ncbi.nlm.nih.gov/pubmed/36384130 http://dx.doi.org/10.1016/j.celrep.2022.111651 |
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