Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested phenotype for years. Upon injury, a rapid phenotypic switch facilitates proliferation to restore tissue perfusion. Here we report the identification of the endothelial cell-enriched long non-coding RNA (lncR...

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Detalles Bibliográficos
Autores principales: Oo, James A., Pálfi, Katalin, Warwick, Timothy, Wittig, Ilka, Prieto-Garcia, Cristian, Matkovic, Vigor, Tomašković, Ines, Boos, Frederike, Izquierdo Ponce, Judit, Teichmann, Tom, Petriukov, Kirill, Haydar, Shaza, Maegdefessel, Lars, Wu, Zhiyuan, Pham, Minh Duc, Krishnan, Jaya, Baker, Andrew H., Günther, Stefan, Ulrich, Helle D., Dikic, Ivan, Leisegang, Matthias S., Brandes, Ralf P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681662/
https://www.ncbi.nlm.nih.gov/pubmed/36384122
http://dx.doi.org/10.1016/j.celrep.2022.111670

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