Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients

Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-g...

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Autores principales: Caudal, Arianne, Mondejar-Parreño, Gema, Vera, Carlos D., Williams, Damon R., Shenoy, Sushma P., Liang, David, Wu, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681708/
https://www.ncbi.nlm.nih.gov/pubmed/35853412
http://dx.doi.org/10.1016/j.scr.2022.102855
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author Caudal, Arianne
Mondejar-Parreño, Gema
Vera, Carlos D.
Williams, Damon R.
Shenoy, Sushma P.
Liang, David
Wu, Joseph C.
author_facet Caudal, Arianne
Mondejar-Parreño, Gema
Vera, Carlos D.
Williams, Damon R.
Shenoy, Sushma P.
Liang, David
Wu, Joseph C.
author_sort Caudal, Arianne
collection PubMed
description Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-gene (PLN). Both iPSC lines exhibited normal morphology, karyotype, pluripotency marker expression, and differentiation into the three germ layers. These patient-specific iPSC lines serve as valuable in vitro models for DCM pathology caused by PLN mutations.
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spelling pubmed-96817082022-11-23 Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients Caudal, Arianne Mondejar-Parreño, Gema Vera, Carlos D. Williams, Damon R. Shenoy, Sushma P. Liang, David Wu, Joseph C. Stem Cell Res Article Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-gene (PLN). Both iPSC lines exhibited normal morphology, karyotype, pluripotency marker expression, and differentiation into the three germ layers. These patient-specific iPSC lines serve as valuable in vitro models for DCM pathology caused by PLN mutations. 2022-08 2022-07-11 /pmc/articles/PMC9681708/ /pubmed/35853412 http://dx.doi.org/10.1016/j.scr.2022.102855 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Caudal, Arianne
Mondejar-Parreño, Gema
Vera, Carlos D.
Williams, Damon R.
Shenoy, Sushma P.
Liang, David
Wu, Joseph C.
Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title_full Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title_fullStr Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title_full_unstemmed Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title_short Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients
title_sort generation of human induced pluripotent stem cell lines carrying heterozygous pln mutation from dilated cardiomyopathy patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681708/
https://www.ncbi.nlm.nih.gov/pubmed/35853412
http://dx.doi.org/10.1016/j.scr.2022.102855
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