Structural basis for activation of DNMT1

DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM structure of human DNMT1 bound to its two natural activators: hemimethylated DNA and ubiquitinated histone H3. We find that...

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Detalles Bibliográficos
Autores principales: Kikuchi, Amika, Onoda, Hiroki, Yamaguchi, Kosuke, Kori, Satomi, Matsuzawa, Shun, Chiba, Yoshie, Tanimoto, Shota, Yoshimi, Sae, Sato, Hiroki, Yamagata, Atsushi, Shirouzu, Mikako, Adachi, Naruhiko, Sharif, Jafar, Koseki, Haruhiko, Nishiyama, Atsuya, Nakanishi, Makoto, Defossez, Pierre-Antoine, Arita, Kyohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681727/
https://www.ncbi.nlm.nih.gov/pubmed/36414620
http://dx.doi.org/10.1038/s41467-022-34779-4

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