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Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

Emerging evidence suggests that osteoarthritis is associated with high cholesterol levels in some osteoarthritis patients. However, the specific mechanism under this metabolic osteoarthritis phenotype remains unclear. We find that cholesterol metabolism-related gene, LRP3 (low-density lipoprotein re...

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Detalles Bibliográficos
Autores principales:	Cao, Chenxi, Shi, Yuanyuan, Zhang, Xin, Li, Qi, Zhang, Jiahao, Zhao, Fengyuan, Meng, Qingyang, Dai, Wenli, Liu, Zhenlong, Yan, Wenqiang, Duan, Xiaoning, Zhang, Jiying, Fu, Xin, Cheng, Jin, Hu, Xiaoqing, Ao, Yingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681739/ https://www.ncbi.nlm.nih.gov/pubmed/36414669 http://dx.doi.org/10.1038/s41467-022-34830-4

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