Cargando…

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4

Emerging evidence suggests that osteoarthritis is associated with high cholesterol levels in some osteoarthritis patients. However, the specific mechanism under this metabolic osteoarthritis phenotype remains unclear. We find that cholesterol metabolism-related gene, LRP3 (low-density lipoprotein re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Chenxi, Shi, Yuanyuan, Zhang, Xin, Li, Qi, Zhang, Jiahao, Zhao, Fengyuan, Meng, Qingyang, Dai, Wenli, Liu, Zhenlong, Yan, Wenqiang, Duan, Xiaoning, Zhang, Jiying, Fu, Xin, Cheng, Jin, Hu, Xiaoqing, Ao, Yingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681739/ https://www.ncbi.nlm.nih.gov/pubmed/36414669 http://dx.doi.org/10.1038/s41467-022-34830-4

Ejemplares similares

Autologous Fractionated Adipose Tissue as a Natural Biomaterial and Novel One-Step Stem Cell Therapy for Repairing Articular Cartilage Defects
por: Li, Qi, et al.
Publicado: (2020)

A novel rabbit model of early osteoarthritis exhibits gradual cartilage degeneration after medial collateral ligament transection outside the joint capsule
por: Liu, Zhenlong, et al.
Publicado: (2016)

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
por: Shi, Yuanyuan, et al.
Publicado: (2019)

Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis
por: Cheng, Jin, et al.
Publicado: (2016)

A composite scaffold of MSC affinity peptide-modified demineralized bone matrix particles and chitosan hydrogel for cartilage regeneration
por: Meng, Qingyang, et al.
Publicado: (2015)

Earlier and More Severe Cartilage Degeneration Occurs After Meniscal Tears in Juvenile Rabbits Compared with Adults
por: Yan, Wenqiang, et al.
Publicado: (2022)

Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies
por: Yan, Wenqiang, et al.
Publicado: (2021)

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation
por: Liu, Qiang, et al.
Publicado: (2016)

Biomechanically, structurally and functionally meticulously tailored polycaprolactone/silk fibroin scaffold for meniscus regeneration
por: Li, Zong, et al.
Publicado: (2020)

The potential of using semitendinosus tendon as autograft in rabbit meniscus reconstruction
por: Li, Chenxi, et al.
Publicado: (2017)

The transplantation of particulated juvenile allograft cartilage and synovium for the repair of meniscal defect in a lapine model
por: Yan, Wenqiang, et al.
Publicado: (2022)

Histologically Confirmed Recellularization is a Key Factor that Affects Meniscal Healing in Immature and Mature Meniscal Tears
por: Yan, Wenqiang, et al.
Publicado: (2021)

3D Printing of Microenvironment‐Specific Bioinspired and Exosome‐Reinforced Hydrogel Scaffolds for Efficient Cartilage and Subchondral Bone Regeneration
por: Li, Qi, et al.
Publicado: (2023)

The TMSB4 Pseudogene LncRNA Functions as a Competing Endogenous RNA to Promote Cartilage Degradation in Human Osteoarthritis
por: Liu, Qiang, et al.
Publicado: (2016)

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7
por: Cheng, Jin, et al.
Publicado: (2021)

Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression
por: Liu, Qiang, et al.
Publicado: (2016)

Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis
por: Cao, Chenxi, et al.
Publicado: (2020)

Silencing of miR-101 Prevents Cartilage Degradation by Regulating Extracellular Matrix–related Genes in a Rat Model of Osteoarthritis
por: Dai, Linghui, et al.
Publicado: (2015)

Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12
por: Dai, Linghui, et al.
Publicado: (2015)

A co-culture system of rat synovial stem cells and meniscus cells promotes cell proliferation and differentiation as compared to mono-culture
por: Xie, Xing, et al.
Publicado: (2018)

Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases
por: Dai, Wenli, et al.
Publicado: (2020)

Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis
por: Liu, Qiang, et al.
Publicado: (2017)

Role of Syndecan-4 in the Inhibition of Articular Cartilage Degeneration in Osteoarthritis
por: Hattori, Yoshio, et al.
Publicado: (2023)

Using a Xenogeneic Acellular Dermal Matrix Membrane to Enhance the Reparability of Bone Marrow Mesenchymal Stem Cells for Cartilage Injury
por: Shi, Weili, et al.
Publicado: (2023)

Meniscal fibrocartilage regeneration inspired by meniscal maturational and regenerative process
por: Yan, Wenqiang, et al.
Publicado: (2023)

Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction
por: Zhang, Xin, et al.
Publicado: (2016)

Finite Element Analysis and Experimental Validation of the Anterior Cruciate Ligament and Implications for the Injury Mechanism
por: Ren, Shuang, et al.
Publicado: (2022)

Classification of Bone Bruises in Pediatric Patients With Anterior Cruciate Ligament Injuries
por: Wang, Hong-De, et al.
Publicado: (2023)

Synthesis and characterization of polyphosphazene microspheres incorporating demineralized bone matrix scaffolds controlled release of growth factor for chondrogenesis applications
por: Ren, Bo, et al.
Publicado: (2017)

Expression of syndecan-1 during development, growth and cartilage degeneration in a transgenic mouse model for osteoarthritis
por: Pirilä, L, et al.
Publicado: (2002)

Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes
por: Dai, Linghui, et al.
Publicado: (2012)

Engineering of MSC-Derived Exosomes: A Promising Cell-Free Therapy for Osteoarthritis
por: Cheng, Jin, et al.
Publicado: (2022)

Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes
por: Sun, Muyang, et al.
Publicado: (2021)

Cellular Cholesterol Distribution Influences Proteolytic Release of the LRP-1 Ectodomain
por: Dekky, Bassil, et al.
Publicado: (2016)

The potential role of necroptosis in clinical diseases (Review)
por: Dai, Wenli, et al.
Publicado: (2021)

Second-Look Arthroscopic Evaluation of Healing Rates After Arthroscopic Repair of Meniscal Tears: A Systematic Review and Meta-analysis
por: Dai, Wenli, et al.
Publicado: (2021)

The effect of fascia iliaca block on postoperative pain and analgesic consumption for patients undergoing primary total hip arthroplasty: a meta-analysis of randomized controlled trials
por: Dai, Wenli, et al.
Publicado: (2021)

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6
por: Wang, Hanqing, et al.
Publicado: (2022)

Bone Bruise Distribution Patterns After Acute Anterior Cruciate Ligament Ruptures: Implications for the Injury Mechanism
por: Shi, Huijuan, et al.
Publicado: (2020)

Comparison Between Soccer and Basketball of Bone Bruise and Meniscal Injury Patterns in Anterior Cruciate Ligament Injuries
por: Shi, Huijuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d0gj7i2111ji2g746u95g742fl