Thermostability and in vivo performance of AAV9 in a film matrix

BACKGROUND: Adeno-associated virus (AAV) vectors are stored and shipped frozen which poses logistic and economic barriers for global access to these therapeutics. To address this issue, we developed a method to stabilize AAV serotype 9 (AAV9) in a film matrix that can be stored at ambient temperatur...

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Detalles Bibliográficos
Autores principales: Doan, Trang Nguyen Kieu, Le, Matthew D., Bajrovic, Irnela, Celentano, Lorne, Krause, Charles, Balyan, Haley Grooms, Svancarek, Abbie, Mote, Angela, Tretiakova, Anna, Jude Samulski, R., Croyle, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681776/
https://www.ncbi.nlm.nih.gov/pubmed/36414773
http://dx.doi.org/10.1038/s43856-022-00212-6

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