A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects

Background: Phosphodiesterase 10A (PDE10A) is expressed almost exclusively in the striatum and its inhibition is suggested to offer potential treatment in disorders associated with basal ganglia. We evaluated the selectivity, cytotoxicity, genotoxicity, pharmacokinetics and potential adverse effects...

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Detalles Bibliográficos
Autores principales: Matloka, Mikolaj, Janowska, Sylwia, Pankiewicz, Piotr, Kokhanovska, Sofiya, Kos, Tomasz, Hołuj, Małgorzata, Rutkowska-Wlodarczyk, Izabela, Abramski, Krzysztof, Janicka, Monika, Jakubowski, Piotr, Świątkiewicz, Maciej, Welniak-Kaminska, Marlena, Hucz-Kalitowska, Joanna, Dera, Paulina, Bojarski, Lukasz, Grieb, Paweł, Popik, Piotr, Wieczorek, Maciej, Pieczykolan, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681820/
https://www.ncbi.nlm.nih.gov/pubmed/36438799
http://dx.doi.org/10.3389/fphar.2022.999685

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