Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS) is a paediatric cancer driven either by fusion proteins (e.g., PAX3-FOXO1) or by mutations in key signalling molecules (e.g., RAS or FGFR4). Despite the latter providing opportunities for precision medicine approaches in RMS, there are currently no such treatments...

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Detalles Bibliográficos
Autores principales: Fiorito, Elisa, Szybowska, Patrycja, Haugsten, Ellen M., Kostas, Michal, Øy, Geir F., Wiedlocha, Antoni, Singh, Sachin, Nakken, Sigve, Mælandsmo, Gunhild M., Fletcher, Jonathan A., Meza-Zepeda, Leonardo A., Wesche, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681859/
https://www.ncbi.nlm.nih.gov/pubmed/36097178
http://dx.doi.org/10.1038/s41416-022-01973-6

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