SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

Activation of RIPK1-driven cell death and inflammation play important roles in the progression of nonalcoholic steatohepatitis (NASH). However, the mechanism underlying RIPK1 activation in NASH remains unclear. Here we identified SENP1, a SUMO-specific protease, as a key endogenous inhibitor of RIPK...

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Detalles Bibliográficos
Autores principales: Yan, Lingjie, Zhang, Tao, Wang, Kai, Chen, Zezhao, Yang, Yuanxin, Shan, Bing, Sun, Qi, Zhang, Mengmeng, Zhang, Yichi, Zhong, Yedan, Liu, Nan, Gu, Jinyang, Xu, Daichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681887/
https://www.ncbi.nlm.nih.gov/pubmed/36414671
http://dx.doi.org/10.1038/s41467-022-34993-0

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