Cargando…
Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report
BACKGROUND: Patients with muscular dystrophy have mutations in the gene that can lead to severe muscle wasting, respiratory issues or heart failure between ages 30 and 40. Currently, there is no effective treatment for DMD-induced heart failure. CASE PRESENTATION: We report a patient with recurrent...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681897/ https://www.ncbi.nlm.nih.gov/pubmed/36440017 http://dx.doi.org/10.3389/fcvm.2022.974843 |
_version_ | 1784834728712470528 |
---|---|
author | Liu, Xuhan Zhao, Wei Shu, Shangzhi Zhang, Weihua |
author_facet | Liu, Xuhan Zhao, Wei Shu, Shangzhi Zhang, Weihua |
author_sort | Liu, Xuhan |
collection | PubMed |
description | BACKGROUND: Patients with muscular dystrophy have mutations in the gene that can lead to severe muscle wasting, respiratory issues or heart failure between ages 30 and 40. Currently, there is no effective treatment for DMD-induced heart failure. CASE PRESENTATION: We report a patient with recurrent unexplained fever and muscle soreness was definitely diagnosed with DMD. An analysis of the patient's genetics revealed a nonsense mutation (C.1207G > T). His DMD was treated with hormones. Also, the patient's fever is under control because of hormone therapy. However, as the disease progresses, the heart structure and function gradually change, and eventually malignant arrhythmias occur. CONCLUSION: We report a rare case of DMD involving the heart causing heart failure and malignant arrhythmia. Currently, no complete treatment is available for these patients, but our treatment regimen may benefit our patient and improve his outcomes. |
format | Online Article Text |
id | pubmed-9681897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96818972022-11-24 Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report Liu, Xuhan Zhao, Wei Shu, Shangzhi Zhang, Weihua Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Patients with muscular dystrophy have mutations in the gene that can lead to severe muscle wasting, respiratory issues or heart failure between ages 30 and 40. Currently, there is no effective treatment for DMD-induced heart failure. CASE PRESENTATION: We report a patient with recurrent unexplained fever and muscle soreness was definitely diagnosed with DMD. An analysis of the patient's genetics revealed a nonsense mutation (C.1207G > T). His DMD was treated with hormones. Also, the patient's fever is under control because of hormone therapy. However, as the disease progresses, the heart structure and function gradually change, and eventually malignant arrhythmias occur. CONCLUSION: We report a rare case of DMD involving the heart causing heart failure and malignant arrhythmia. Currently, no complete treatment is available for these patients, but our treatment regimen may benefit our patient and improve his outcomes. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9681897/ /pubmed/36440017 http://dx.doi.org/10.3389/fcvm.2022.974843 Text en Copyright © 2022 Liu, Zhao, Shu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Liu, Xuhan Zhao, Wei Shu, Shangzhi Zhang, Weihua Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title | Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title_full | Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title_fullStr | Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title_full_unstemmed | Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title_short | Duchenne muscular dystrophy involves the myocardium and causes arrhythmia: Case report |
title_sort | duchenne muscular dystrophy involves the myocardium and causes arrhythmia: case report |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681897/ https://www.ncbi.nlm.nih.gov/pubmed/36440017 http://dx.doi.org/10.3389/fcvm.2022.974843 |
work_keys_str_mv | AT liuxuhan duchennemusculardystrophyinvolvesthemyocardiumandcausesarrhythmiacasereport AT zhaowei duchennemusculardystrophyinvolvesthemyocardiumandcausesarrhythmiacasereport AT shushangzhi duchennemusculardystrophyinvolvesthemyocardiumandcausesarrhythmiacasereport AT zhangweihua duchennemusculardystrophyinvolvesthemyocardiumandcausesarrhythmiacasereport |