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Prospective population pharmacokinetic study of tacrolimus in adult recipients early after liver transplantation: A comparison of Michaelis-Menten and theory-based pharmacokinetic models

Background and Objective: Tacrolimus, a calcineurin inhibitor widely used as a potent immunosuppressant to prevent graft rejection, exhibits nonlinear kinetics in patients with kidney transplantation and nephrotic syndrome. However, whether nonlinear drug metabolism occurs in adult patients undergoi...

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Detalles Bibliográficos
Autores principales:	Cai, Xiao-Jun, Li, Rui-Dong, Li, Jian-Hua, Tao, Yi-Feng, Zhang, Quan-Bao, Shen, Cong-Huan, Zhang, Xiao-Fei, Wang, Zheng-Xin, Jiao, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681907/ https://www.ncbi.nlm.nih.gov/pubmed/36438793 http://dx.doi.org/10.3389/fphar.2022.1031969

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