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MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study
INTRODUCTION: Although magnetic resonance imaging (MRI) is an important modality for the diagnosis of metastatic spinal cord compression (MSCC), there are only a few reports on MSCC findings and symptoms after radiotherapy. We aimed to reveal the factors related to ambulatory function after treatmen...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681941/ https://www.ncbi.nlm.nih.gov/pubmed/35852785 http://dx.doi.org/10.1007/s40487-022-00204-5 |
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author | Yano, Natsuko Ono, Takashi Suzuki, Tomoto Sugai, Yasuhiro Yamada, Masayoshi Kawashiro, Shohei Harada, Mayumi Akamatsu, Hiroko Hagiwara, Yasuhito Ichikawa, Mayumi Sato, Hiraku Takagi, Michiaki Kanoto, Masafumi Nemoto, Kenji |
author_facet | Yano, Natsuko Ono, Takashi Suzuki, Tomoto Sugai, Yasuhiro Yamada, Masayoshi Kawashiro, Shohei Harada, Mayumi Akamatsu, Hiroko Hagiwara, Yasuhito Ichikawa, Mayumi Sato, Hiraku Takagi, Michiaki Kanoto, Masafumi Nemoto, Kenji |
author_sort | Yano, Natsuko |
collection | PubMed |
description | INTRODUCTION: Although magnetic resonance imaging (MRI) is an important modality for the diagnosis of metastatic spinal cord compression (MSCC), there are only a few reports on MSCC findings and symptoms after radiotherapy. We aimed to reveal the factors related to ambulatory function after treatment, including the MRI findings, in a prospective observational study. METHODS: Patients with suspected MSCC who were treated with radiotherapy were included in this study. Orthopedic surgeons evaluated the neurological function according to the Frankel grade. All patients underwent spinal MRI, and the degree of spinal cord compression was assessed by a radiologist and a radiation oncologist using an MRI grading scale. One month after treatment, orthopedic surgeons reassessed the Frankel grade. Twenty-three patients who were evaluated 1 month after radiotherapy were included in the analysis. RESULTS: Before radiotherapy, 17 patients were ambulatory and six were unable to walk. Furthermore, 13 patients were diagnosed with grade 3 compression on MRI (spinal cord compression with no cerebrospinal fluid seen on axial T2-weighted imaging). Patients with grade 3 MSCC were significantly more likely to be non-ambulatory at 1 month. CONCLUSIONS: The MRI grading scale for MSCC may be a prognostic factor for ambulatory function after radiotherapy. MRI findings could aid in determining the indication for radiotherapy. |
format | Online Article Text |
id | pubmed-9681941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-96819412022-11-24 MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study Yano, Natsuko Ono, Takashi Suzuki, Tomoto Sugai, Yasuhiro Yamada, Masayoshi Kawashiro, Shohei Harada, Mayumi Akamatsu, Hiroko Hagiwara, Yasuhito Ichikawa, Mayumi Sato, Hiraku Takagi, Michiaki Kanoto, Masafumi Nemoto, Kenji Oncol Ther Brief Report INTRODUCTION: Although magnetic resonance imaging (MRI) is an important modality for the diagnosis of metastatic spinal cord compression (MSCC), there are only a few reports on MSCC findings and symptoms after radiotherapy. We aimed to reveal the factors related to ambulatory function after treatment, including the MRI findings, in a prospective observational study. METHODS: Patients with suspected MSCC who were treated with radiotherapy were included in this study. Orthopedic surgeons evaluated the neurological function according to the Frankel grade. All patients underwent spinal MRI, and the degree of spinal cord compression was assessed by a radiologist and a radiation oncologist using an MRI grading scale. One month after treatment, orthopedic surgeons reassessed the Frankel grade. Twenty-three patients who were evaluated 1 month after radiotherapy were included in the analysis. RESULTS: Before radiotherapy, 17 patients were ambulatory and six were unable to walk. Furthermore, 13 patients were diagnosed with grade 3 compression on MRI (spinal cord compression with no cerebrospinal fluid seen on axial T2-weighted imaging). Patients with grade 3 MSCC were significantly more likely to be non-ambulatory at 1 month. CONCLUSIONS: The MRI grading scale for MSCC may be a prognostic factor for ambulatory function after radiotherapy. MRI findings could aid in determining the indication for radiotherapy. Springer Healthcare 2022-07-19 /pmc/articles/PMC9681941/ /pubmed/35852785 http://dx.doi.org/10.1007/s40487-022-00204-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Brief Report Yano, Natsuko Ono, Takashi Suzuki, Tomoto Sugai, Yasuhiro Yamada, Masayoshi Kawashiro, Shohei Harada, Mayumi Akamatsu, Hiroko Hagiwara, Yasuhito Ichikawa, Mayumi Sato, Hiraku Takagi, Michiaki Kanoto, Masafumi Nemoto, Kenji MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title | MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title_full | MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title_fullStr | MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title_full_unstemmed | MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title_short | MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study |
title_sort | mri grading scale predicts ambulatory function after radiotherapy for metastatic spinal cord compression: a prospective single-institution observational study |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681941/ https://www.ncbi.nlm.nih.gov/pubmed/35852785 http://dx.doi.org/10.1007/s40487-022-00204-5 |
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