The role of long noncoding RNAs in therapeutic resistance in cervical cancer

Cervical cancer is one of the common tumors and often causes cancer-related death in women. Chemotherapy is a common cancer therapy, which displays a pivotal clinical benefit for cancer patients. However, chemoresistance becomes a big obstacle for failure of treatment in cancer patients. Recently, l...

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Detalles Bibliográficos
Autores principales: Zhou, Meimei, Liu, Linlin, Wang, Jing, Liu, Wanru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682114/
https://www.ncbi.nlm.nih.gov/pubmed/36438563
http://dx.doi.org/10.3389/fcell.2022.1060909
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author Zhou, Meimei
Liu, Linlin
Wang, Jing
Liu, Wanru
author_facet Zhou, Meimei
Liu, Linlin
Wang, Jing
Liu, Wanru
author_sort Zhou, Meimei
collection PubMed
description Cervical cancer is one of the common tumors and often causes cancer-related death in women. Chemotherapy is a common cancer therapy, which displays a pivotal clinical benefit for cancer patients. However, chemoresistance becomes a big obstacle for failure of treatment in cancer patients. Recently, long noncoding RNAs (lncRNAs) have been identified to regulate drug resistance in human cancers, including cervical cancer. In this review, we describe the role of lncRNAs in regulation of chemotherapeutic resistance in cervical cancer. We also discuss the molecular mechanisms of lncRNA-mediated drug resistance in cervical cancer. Moreover, we describe that targeting lncRNAs could reverse drug resistance in cervical cancer. Therefore, lncRNAs could become effective therapeutic targets and chemotherapeutic sensitizers for cervical cancer patients.
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spelling pubmed-96821142022-11-24 The role of long noncoding RNAs in therapeutic resistance in cervical cancer Zhou, Meimei Liu, Linlin Wang, Jing Liu, Wanru Front Cell Dev Biol Cell and Developmental Biology Cervical cancer is one of the common tumors and often causes cancer-related death in women. Chemotherapy is a common cancer therapy, which displays a pivotal clinical benefit for cancer patients. However, chemoresistance becomes a big obstacle for failure of treatment in cancer patients. Recently, long noncoding RNAs (lncRNAs) have been identified to regulate drug resistance in human cancers, including cervical cancer. In this review, we describe the role of lncRNAs in regulation of chemotherapeutic resistance in cervical cancer. We also discuss the molecular mechanisms of lncRNA-mediated drug resistance in cervical cancer. Moreover, we describe that targeting lncRNAs could reverse drug resistance in cervical cancer. Therefore, lncRNAs could become effective therapeutic targets and chemotherapeutic sensitizers for cervical cancer patients. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9682114/ /pubmed/36438563 http://dx.doi.org/10.3389/fcell.2022.1060909 Text en Copyright © 2022 Zhou, Liu, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhou, Meimei
Liu, Linlin
Wang, Jing
Liu, Wanru
The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title_full The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title_fullStr The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title_full_unstemmed The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title_short The role of long noncoding RNAs in therapeutic resistance in cervical cancer
title_sort role of long noncoding rnas in therapeutic resistance in cervical cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682114/
https://www.ncbi.nlm.nih.gov/pubmed/36438563
http://dx.doi.org/10.3389/fcell.2022.1060909
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