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Gyrification in relation to cortical thickness in the congenitally blind
Greater cortical gyrification (GY) is linked with enhanced cognitive abilities and is also negatively related to cortical thickness (CT). Individuals who are congenitally blind (CB) exhibits remarkable functional brain plasticity which enables them to perform certain non-visual and cognitive tasks w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682146/ https://www.ncbi.nlm.nih.gov/pubmed/36440286 http://dx.doi.org/10.3389/fnins.2022.970878 |
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author | Arend, Isabel Yuen, Kenneth Yizhar, Or Chebat, Daniel-Robert Amedi, Amir |
author_facet | Arend, Isabel Yuen, Kenneth Yizhar, Or Chebat, Daniel-Robert Amedi, Amir |
author_sort | Arend, Isabel |
collection | PubMed |
description | Greater cortical gyrification (GY) is linked with enhanced cognitive abilities and is also negatively related to cortical thickness (CT). Individuals who are congenitally blind (CB) exhibits remarkable functional brain plasticity which enables them to perform certain non-visual and cognitive tasks with supranormal abilities. For instance, extensive training using touch and audition enables CB people to develop impressive skills and there is evidence linking these skills to cross-modal activations of primary visual areas. There is a cascade of anatomical, morphometric and functional-connectivity changes in non-visual structures, volumetric reductions in several components of the visual system, and CT is also increased in CB. No study to date has explored GY changes in this population, and no study has explored how variations in CT are related to GY changes in CB. T1-weighted 3D structural magnetic resonance imaging scans were acquired to examine the effects of congenital visual deprivation in cortical structures in a healthy sample of 11 CB individuals (6 male) and 16 age-matched sighted controls (SC) (10 male). In this report, we show for the first time an increase in GY in several brain areas of CB individuals compared to SC, and a negative relationship between GY and CT in the CB brain in several different cortical areas. We discuss the implications of our findings and the contributions of developmental factors and synaptogenesis to the relationship between CT and GY in CB individuals compared to SC. F. |
format | Online Article Text |
id | pubmed-9682146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96821462022-11-24 Gyrification in relation to cortical thickness in the congenitally blind Arend, Isabel Yuen, Kenneth Yizhar, Or Chebat, Daniel-Robert Amedi, Amir Front Neurosci Neuroscience Greater cortical gyrification (GY) is linked with enhanced cognitive abilities and is also negatively related to cortical thickness (CT). Individuals who are congenitally blind (CB) exhibits remarkable functional brain plasticity which enables them to perform certain non-visual and cognitive tasks with supranormal abilities. For instance, extensive training using touch and audition enables CB people to develop impressive skills and there is evidence linking these skills to cross-modal activations of primary visual areas. There is a cascade of anatomical, morphometric and functional-connectivity changes in non-visual structures, volumetric reductions in several components of the visual system, and CT is also increased in CB. No study to date has explored GY changes in this population, and no study has explored how variations in CT are related to GY changes in CB. T1-weighted 3D structural magnetic resonance imaging scans were acquired to examine the effects of congenital visual deprivation in cortical structures in a healthy sample of 11 CB individuals (6 male) and 16 age-matched sighted controls (SC) (10 male). In this report, we show for the first time an increase in GY in several brain areas of CB individuals compared to SC, and a negative relationship between GY and CT in the CB brain in several different cortical areas. We discuss the implications of our findings and the contributions of developmental factors and synaptogenesis to the relationship between CT and GY in CB individuals compared to SC. F. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9682146/ /pubmed/36440286 http://dx.doi.org/10.3389/fnins.2022.970878 Text en Copyright © 2022 Arend, Yuen, Yizhar, Chebat and Amedi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Arend, Isabel Yuen, Kenneth Yizhar, Or Chebat, Daniel-Robert Amedi, Amir Gyrification in relation to cortical thickness in the congenitally blind |
title | Gyrification in relation to cortical thickness in the congenitally blind |
title_full | Gyrification in relation to cortical thickness in the congenitally blind |
title_fullStr | Gyrification in relation to cortical thickness in the congenitally blind |
title_full_unstemmed | Gyrification in relation to cortical thickness in the congenitally blind |
title_short | Gyrification in relation to cortical thickness in the congenitally blind |
title_sort | gyrification in relation to cortical thickness in the congenitally blind |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682146/ https://www.ncbi.nlm.nih.gov/pubmed/36440286 http://dx.doi.org/10.3389/fnins.2022.970878 |
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