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Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury

Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestin...

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Autores principales: Zhang, Yiwen, Lang, Rui, Guo, Shunyu, Luo, Xiaoqin, Li, Huiting, Liu, Cencen, Dong, Wei, Bao, Changshun, Yu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682189/
https://www.ncbi.nlm.nih.gov/pubmed/36440294
http://dx.doi.org/10.3389/fnins.2022.981772
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author Zhang, Yiwen
Lang, Rui
Guo, Shunyu
Luo, Xiaoqin
Li, Huiting
Liu, Cencen
Dong, Wei
Bao, Changshun
Yu, Yang
author_facet Zhang, Yiwen
Lang, Rui
Guo, Shunyu
Luo, Xiaoqin
Li, Huiting
Liu, Cencen
Dong, Wei
Bao, Changshun
Yu, Yang
author_sort Zhang, Yiwen
collection PubMed
description Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.
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spelling pubmed-96821892022-11-24 Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury Zhang, Yiwen Lang, Rui Guo, Shunyu Luo, Xiaoqin Li, Huiting Liu, Cencen Dong, Wei Bao, Changshun Yu, Yang Front Neurosci Neuroscience Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9682189/ /pubmed/36440294 http://dx.doi.org/10.3389/fnins.2022.981772 Text en Copyright © 2022 Zhang, Lang, Guo, Luo, Li, Liu, Dong, Bao and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Yiwen
Lang, Rui
Guo, Shunyu
Luo, Xiaoqin
Li, Huiting
Liu, Cencen
Dong, Wei
Bao, Changshun
Yu, Yang
Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title_full Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title_fullStr Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title_full_unstemmed Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title_short Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
title_sort intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682189/
https://www.ncbi.nlm.nih.gov/pubmed/36440294
http://dx.doi.org/10.3389/fnins.2022.981772
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