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Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study
BACKGROUND: Detection of glandular abnormalities in Papanicolaou (Pap) tests is challenging. This study aimed to review our institute’s experience interpreting such abnormalities, assess cytohistologic concordance, and identify cytomorphologic features associated with malignancy in follow-up histolo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Pathologists and the Korean Society for Cytopathology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682225/ https://www.ncbi.nlm.nih.gov/pubmed/36345619 http://dx.doi.org/10.4132/jptm.2022.09.05 |
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author | Sung, Jung-A Nikas, Ilias P. Kim, Haeryoung Ryu, Han Suk Lee, Cheol |
author_facet | Sung, Jung-A Nikas, Ilias P. Kim, Haeryoung Ryu, Han Suk Lee, Cheol |
author_sort | Sung, Jung-A |
collection | PubMed |
description | BACKGROUND: Detection of glandular abnormalities in Papanicolaou (Pap) tests is challenging. This study aimed to review our institute’s experience interpreting such abnormalities, assess cytohistologic concordance, and identify cytomorphologic features associated with malignancy in follow-up histology. METHODS: Patients with cytologically-detected glandular lesions identified in our pathology records from 1995 to 2020 were included in this study. RESULTS: Of the 683,197 Pap tests performed, 985 (0.144%) exhibited glandular abnormalities, 657 of which had tissue follow-up available. One hundred eighty-eight cases were cytologically interpreted as adenocarcinoma and histologically diagnosed as malignant tumors of various origins. There were 213 cases reported as atypical glandular cells (AGC) and nine cases as adenocarcinoma in cytology, yet they were found to be benign in follow-up histology. In addition, 48 cases diagnosed with AGC and six with adenocarcinoma cytology were found to have cervical squamous lesions in follow-up histology, including four squamous cell carcinomas. Among the cytomorphological features examined, nuclear membrane irregularity, three-dimensional clusters, single-cell pattern, and presence of mitoses were associated with malignant histology in follow-up. CONCLUSIONS: This study showed our institute’s experience detecting glandular abnormalities in cervical cytology over a 25-year period, revealing the difficulty of this task. Nonetheless, the present study indicates that several cytological findings such as membrane irregularity, three-dimensional clusters, single-cell pattern, and evidence of proliferation could help distinguishing malignancy from a benign lesion. |
format | Online Article Text |
id | pubmed-9682225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-96822252022-12-05 Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study Sung, Jung-A Nikas, Ilias P. Kim, Haeryoung Ryu, Han Suk Lee, Cheol J Pathol Transl Med Original Article BACKGROUND: Detection of glandular abnormalities in Papanicolaou (Pap) tests is challenging. This study aimed to review our institute’s experience interpreting such abnormalities, assess cytohistologic concordance, and identify cytomorphologic features associated with malignancy in follow-up histology. METHODS: Patients with cytologically-detected glandular lesions identified in our pathology records from 1995 to 2020 were included in this study. RESULTS: Of the 683,197 Pap tests performed, 985 (0.144%) exhibited glandular abnormalities, 657 of which had tissue follow-up available. One hundred eighty-eight cases were cytologically interpreted as adenocarcinoma and histologically diagnosed as malignant tumors of various origins. There were 213 cases reported as atypical glandular cells (AGC) and nine cases as adenocarcinoma in cytology, yet they were found to be benign in follow-up histology. In addition, 48 cases diagnosed with AGC and six with adenocarcinoma cytology were found to have cervical squamous lesions in follow-up histology, including four squamous cell carcinomas. Among the cytomorphological features examined, nuclear membrane irregularity, three-dimensional clusters, single-cell pattern, and presence of mitoses were associated with malignant histology in follow-up. CONCLUSIONS: This study showed our institute’s experience detecting glandular abnormalities in cervical cytology over a 25-year period, revealing the difficulty of this task. Nonetheless, the present study indicates that several cytological findings such as membrane irregularity, three-dimensional clusters, single-cell pattern, and evidence of proliferation could help distinguishing malignancy from a benign lesion. The Korean Society of Pathologists and the Korean Society for Cytopathology 2022-11 2022-11-09 /pmc/articles/PMC9682225/ /pubmed/36345619 http://dx.doi.org/10.4132/jptm.2022.09.05 Text en © 2022 The Korean Society of Pathologists/The Korean Society for Cytopathology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sung, Jung-A Nikas, Ilias P. Kim, Haeryoung Ryu, Han Suk Lee, Cheol Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title | Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title_full | Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title_fullStr | Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title_full_unstemmed | Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title_short | Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
title_sort | diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682225/ https://www.ncbi.nlm.nih.gov/pubmed/36345619 http://dx.doi.org/10.4132/jptm.2022.09.05 |
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