The role of TIGAR in nervous system diseases

TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions incl...

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Detalles Bibliográficos
Autores principales: Huang, Bei, Lang, Xiaoling, Li, Xihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682291/
https://www.ncbi.nlm.nih.gov/pubmed/36437984
http://dx.doi.org/10.3389/fnagi.2022.1023161
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author Huang, Bei
Lang, Xiaoling
Li, Xihong
author_facet Huang, Bei
Lang, Xiaoling
Li, Xihong
author_sort Huang, Bei
collection PubMed
description TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.
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spelling pubmed-96822912022-11-24 The role of TIGAR in nervous system diseases Huang, Bei Lang, Xiaoling Li, Xihong Front Aging Neurosci Aging Neuroscience TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9682291/ /pubmed/36437984 http://dx.doi.org/10.3389/fnagi.2022.1023161 Text en Copyright © 2022 Huang, Lang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Huang, Bei
Lang, Xiaoling
Li, Xihong
The role of TIGAR in nervous system diseases
title The role of TIGAR in nervous system diseases
title_full The role of TIGAR in nervous system diseases
title_fullStr The role of TIGAR in nervous system diseases
title_full_unstemmed The role of TIGAR in nervous system diseases
title_short The role of TIGAR in nervous system diseases
title_sort role of tigar in nervous system diseases
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682291/
https://www.ncbi.nlm.nih.gov/pubmed/36437984
http://dx.doi.org/10.3389/fnagi.2022.1023161
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