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Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans
Temperature is a critically important factor in many infectious disease systems, because it can regulate responses in both the host and the pathogen. White-nose syndrome (WNS) in bats is a severe infectious disease caused by the temperature-sensitive fungus, Pseudogymnoascus destructans (Pd). One fe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682300/ https://www.ncbi.nlm.nih.gov/pubmed/36425515 http://dx.doi.org/10.1098/rsos.211986 |
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author | Forney, Ronny Rios-Sotelo, Gabriela Lindauer, Alexa Willis, Craig K. R. Voyles, Jamie |
author_facet | Forney, Ronny Rios-Sotelo, Gabriela Lindauer, Alexa Willis, Craig K. R. Voyles, Jamie |
author_sort | Forney, Ronny |
collection | PubMed |
description | Temperature is a critically important factor in many infectious disease systems, because it can regulate responses in both the host and the pathogen. White-nose syndrome (WNS) in bats is a severe infectious disease caused by the temperature-sensitive fungus, Pseudogymnoascus destructans (Pd). One feature of WNS is an increase in the frequency of arousal bouts (i.e. when bat body temperatures are elevated) in Pd-infected bats during hibernation. While several studies have proposed that increased frequency of arousals may play a role in the pathophysiology of WNS, it is unknown if the temperature fluctuations might mediate Pd growth. We hypothesized that exposure to a high frequency of elevated temperatures would reduce Pd growth due to thermal constraints on the pathogen. We simulated the thermal conditions for arousal bouts of uninfected and infected bats during hibernation (fluctuating from 8 to 25°C at two different rates) and quantified Pd growth in vitro. We found that increased exposure to high temperatures significantly reduced Pd growth. Because temperature is one of the most critical abiotic factors mediating host–pathogen interactions, resolving how Pd responds to fluctuating temperatures will provide insights for understanding WNS in bats and other fungal diseases. |
format | Online Article Text |
id | pubmed-9682300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-96823002022-11-23 Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans Forney, Ronny Rios-Sotelo, Gabriela Lindauer, Alexa Willis, Craig K. R. Voyles, Jamie R Soc Open Sci Ecology, Conservation and Global Change Biology Temperature is a critically important factor in many infectious disease systems, because it can regulate responses in both the host and the pathogen. White-nose syndrome (WNS) in bats is a severe infectious disease caused by the temperature-sensitive fungus, Pseudogymnoascus destructans (Pd). One feature of WNS is an increase in the frequency of arousal bouts (i.e. when bat body temperatures are elevated) in Pd-infected bats during hibernation. While several studies have proposed that increased frequency of arousals may play a role in the pathophysiology of WNS, it is unknown if the temperature fluctuations might mediate Pd growth. We hypothesized that exposure to a high frequency of elevated temperatures would reduce Pd growth due to thermal constraints on the pathogen. We simulated the thermal conditions for arousal bouts of uninfected and infected bats during hibernation (fluctuating from 8 to 25°C at two different rates) and quantified Pd growth in vitro. We found that increased exposure to high temperatures significantly reduced Pd growth. Because temperature is one of the most critical abiotic factors mediating host–pathogen interactions, resolving how Pd responds to fluctuating temperatures will provide insights for understanding WNS in bats and other fungal diseases. The Royal Society 2022-11-23 /pmc/articles/PMC9682300/ /pubmed/36425515 http://dx.doi.org/10.1098/rsos.211986 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Ecology, Conservation and Global Change Biology Forney, Ronny Rios-Sotelo, Gabriela Lindauer, Alexa Willis, Craig K. R. Voyles, Jamie Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title | Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title_full | Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title_fullStr | Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title_full_unstemmed | Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title_short | Temperature shifts associated with bat arousals during hibernation inhibit the growth of Pseudogymnoascus destructans |
title_sort | temperature shifts associated with bat arousals during hibernation inhibit the growth of pseudogymnoascus destructans |
topic | Ecology, Conservation and Global Change Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682300/ https://www.ncbi.nlm.nih.gov/pubmed/36425515 http://dx.doi.org/10.1098/rsos.211986 |
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