Cargando…

Recent advances in NIR-II fluorescence based theranostic approaches for glioma

Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful stra...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jiaying, Ling, Jue, Yao, Chaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682463/
https://www.ncbi.nlm.nih.gov/pubmed/36438867
http://dx.doi.org/10.3389/fchem.2022.1054913
_version_ 1784834857510109184
author Li, Jiaying
Ling, Jue
Yao, Chaoyi
author_facet Li, Jiaying
Ling, Jue
Yao, Chaoyi
author_sort Li, Jiaying
collection PubMed
description Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the in vivo detection of gliomas via fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment.
format Online
Article
Text
id pubmed-9682463
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96824632022-11-24 Recent advances in NIR-II fluorescence based theranostic approaches for glioma Li, Jiaying Ling, Jue Yao, Chaoyi Front Chem Chemistry Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the in vivo detection of gliomas via fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9682463/ /pubmed/36438867 http://dx.doi.org/10.3389/fchem.2022.1054913 Text en Copyright © 2022 Li, Ling and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Li, Jiaying
Ling, Jue
Yao, Chaoyi
Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title_full Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title_fullStr Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title_full_unstemmed Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title_short Recent advances in NIR-II fluorescence based theranostic approaches for glioma
title_sort recent advances in nir-ii fluorescence based theranostic approaches for glioma
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682463/
https://www.ncbi.nlm.nih.gov/pubmed/36438867
http://dx.doi.org/10.3389/fchem.2022.1054913
work_keys_str_mv AT lijiaying recentadvancesinniriifluorescencebasedtheranosticapproachesforglioma
AT lingjue recentadvancesinniriifluorescencebasedtheranosticapproachesforglioma
AT yaochaoyi recentadvancesinniriifluorescencebasedtheranosticapproachesforglioma