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Recent advances in NIR-II fluorescence based theranostic approaches for glioma
Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful stra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682463/ https://www.ncbi.nlm.nih.gov/pubmed/36438867 http://dx.doi.org/10.3389/fchem.2022.1054913 |
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author | Li, Jiaying Ling, Jue Yao, Chaoyi |
author_facet | Li, Jiaying Ling, Jue Yao, Chaoyi |
author_sort | Li, Jiaying |
collection | PubMed |
description | Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the in vivo detection of gliomas via fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment. |
format | Online Article Text |
id | pubmed-9682463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96824632022-11-24 Recent advances in NIR-II fluorescence based theranostic approaches for glioma Li, Jiaying Ling, Jue Yao, Chaoyi Front Chem Chemistry Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge. The recent development of near infrared (NIR) II (1000–1700 nm) theranostic agents has led to powerful strategies in diagnosis, targeted delivery of drugs, and accurate therapy. Because of the high capacity of NIR-II light in deep tissue penetration, improved spatiotemporal resolution can be achieved to facilitate the in vivo detection of gliomas via fluorescence imaging, and high contrast fluorescence imaging guided surgery can be realized. In addition to the precise imaging of tumors, drug delivery nano-platforms with NIR-II agents also allow the delivery process to be monitored in real-time. In addition, the combination of targeted drug delivery, photodynamic therapy, and photothermal therapy in the NIR region significantly improves the therapeutic effect against gliomas. Thus, this mini-review summarizes the recent developments in NIR-II fluorescence-based theranostic agents for glioma treatment. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9682463/ /pubmed/36438867 http://dx.doi.org/10.3389/fchem.2022.1054913 Text en Copyright © 2022 Li, Ling and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Li, Jiaying Ling, Jue Yao, Chaoyi Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title | Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title_full | Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title_fullStr | Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title_full_unstemmed | Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title_short | Recent advances in NIR-II fluorescence based theranostic approaches for glioma |
title_sort | recent advances in nir-ii fluorescence based theranostic approaches for glioma |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682463/ https://www.ncbi.nlm.nih.gov/pubmed/36438867 http://dx.doi.org/10.3389/fchem.2022.1054913 |
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