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Antimicrobial Shape Memory Polymer Hydrogels for Chronic Wound Dressings
[Image: see text] Chronic wounds can remain open for several months and have high risks of amputation due to infection. Dressing materials to treat chronic wounds should be conformable for irregular wound geometries, maintain a moist wound bed, and reduce infection risks. To that end, we developed c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682482/ https://www.ncbi.nlm.nih.gov/pubmed/36257053 http://dx.doi.org/10.1021/acsabm.2c00617 |
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author | Vakil, Anand Utpal Ramezani, Maryam Monroe, Mary Beth B. |
author_facet | Vakil, Anand Utpal Ramezani, Maryam Monroe, Mary Beth B. |
author_sort | Vakil, Anand Utpal |
collection | PubMed |
description | [Image: see text] Chronic wounds can remain open for several months and have high risks of amputation due to infection. Dressing materials to treat chronic wounds should be conformable for irregular wound geometries, maintain a moist wound bed, and reduce infection risks. To that end, we developed cytocompatible shape memory polyurethane-based poly(ethylene glycol) (PEG) hydrogels that allow facile delivery to the wound site. Plant-based phenolic acids were physically incorporated onto the hydrogel scaffolds to provide antimicrobial properties. These materials were tested to confirm their shape memory properties, cytocompatibility, and antibacterial properties. The incorporation of phenolic acids provides a new mechanism for tuning intermolecular bonding in the hydrogels and corollary mechanical and shape memory properties. Phenolic acid-containing hydrogels demonstrated an increased shape recovery ratio (1.35× higher than the control formulation), and materials with cytocompatibility >90% were identified. Antimicrobial properties were retained over 20 days in hydrogels with higher phenolic acid content. Phenolic acid retention and antimicrobial efficacy were dependent upon phenolic acid structures and interactions with the polymer backbone. This novel hydrogel system provides a platform for future development as a chronic wound dressing material that is easy to implant and reduces infection risks. |
format | Online Article Text |
id | pubmed-9682482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-96824822022-11-24 Antimicrobial Shape Memory Polymer Hydrogels for Chronic Wound Dressings Vakil, Anand Utpal Ramezani, Maryam Monroe, Mary Beth B. ACS Appl Bio Mater [Image: see text] Chronic wounds can remain open for several months and have high risks of amputation due to infection. Dressing materials to treat chronic wounds should be conformable for irregular wound geometries, maintain a moist wound bed, and reduce infection risks. To that end, we developed cytocompatible shape memory polyurethane-based poly(ethylene glycol) (PEG) hydrogels that allow facile delivery to the wound site. Plant-based phenolic acids were physically incorporated onto the hydrogel scaffolds to provide antimicrobial properties. These materials were tested to confirm their shape memory properties, cytocompatibility, and antibacterial properties. The incorporation of phenolic acids provides a new mechanism for tuning intermolecular bonding in the hydrogels and corollary mechanical and shape memory properties. Phenolic acid-containing hydrogels demonstrated an increased shape recovery ratio (1.35× higher than the control formulation), and materials with cytocompatibility >90% were identified. Antimicrobial properties were retained over 20 days in hydrogels with higher phenolic acid content. Phenolic acid retention and antimicrobial efficacy were dependent upon phenolic acid structures and interactions with the polymer backbone. This novel hydrogel system provides a platform for future development as a chronic wound dressing material that is easy to implant and reduces infection risks. American Chemical Society 2022-10-18 2022-11-21 /pmc/articles/PMC9682482/ /pubmed/36257053 http://dx.doi.org/10.1021/acsabm.2c00617 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Vakil, Anand Utpal Ramezani, Maryam Monroe, Mary Beth B. Antimicrobial Shape Memory Polymer Hydrogels for Chronic Wound Dressings |
title | Antimicrobial Shape Memory Polymer Hydrogels for Chronic
Wound Dressings |
title_full | Antimicrobial Shape Memory Polymer Hydrogels for Chronic
Wound Dressings |
title_fullStr | Antimicrobial Shape Memory Polymer Hydrogels for Chronic
Wound Dressings |
title_full_unstemmed | Antimicrobial Shape Memory Polymer Hydrogels for Chronic
Wound Dressings |
title_short | Antimicrobial Shape Memory Polymer Hydrogels for Chronic
Wound Dressings |
title_sort | antimicrobial shape memory polymer hydrogels for chronic
wound dressings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682482/ https://www.ncbi.nlm.nih.gov/pubmed/36257053 http://dx.doi.org/10.1021/acsabm.2c00617 |
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