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Ferroptosis: A New Promising Target for Ovarian Cancer Therapy

Ferroptosis is a novel kind of regulated cell death distinct from autophagy, apoptosis, and necrosis; it is predominantly caused by the iron-dependent lipid peroxidation. According to studies, numerous conventional signaling pathways and biological processes are implicated in the process of ferropto...

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Detalles Bibliográficos
Autores principales: Zhao, Hongjiang, Xu, Yuan, Shang, Hongkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682507/
https://www.ncbi.nlm.nih.gov/pubmed/36438923
http://dx.doi.org/10.7150/ijms.76480
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author Zhao, Hongjiang
Xu, Yuan
Shang, Hongkai
author_facet Zhao, Hongjiang
Xu, Yuan
Shang, Hongkai
author_sort Zhao, Hongjiang
collection PubMed
description Ferroptosis is a novel kind of regulated cell death distinct from autophagy, apoptosis, and necrosis; it is predominantly caused by the iron-dependent lipid peroxidation. According to studies, numerous conventional signaling pathways and biological processes are implicated in the process of ferroptosis. In recent years, researchers have shown that ferroptosis plays an important role in the genesis, development, and metastasis of malignancies, including ovarian cancer. Several studies have revealed that ferroptosis has synergistic effects with chemotherapy, radiotherapy, and immunotherapy in inhibiting the growth of ovarian cancer cells. This suggests that ferroptosis is important in ovarian cancer treatment and may be a new target. In this review, we summarize the features of ferroptosis, including its underlying basis and function in ovarian cancer, as well as its potential applications in the treatment of ovarian cancer.
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spelling pubmed-96825072022-11-25 Ferroptosis: A New Promising Target for Ovarian Cancer Therapy Zhao, Hongjiang Xu, Yuan Shang, Hongkai Int J Med Sci Review Ferroptosis is a novel kind of regulated cell death distinct from autophagy, apoptosis, and necrosis; it is predominantly caused by the iron-dependent lipid peroxidation. According to studies, numerous conventional signaling pathways and biological processes are implicated in the process of ferroptosis. In recent years, researchers have shown that ferroptosis plays an important role in the genesis, development, and metastasis of malignancies, including ovarian cancer. Several studies have revealed that ferroptosis has synergistic effects with chemotherapy, radiotherapy, and immunotherapy in inhibiting the growth of ovarian cancer cells. This suggests that ferroptosis is important in ovarian cancer treatment and may be a new target. In this review, we summarize the features of ferroptosis, including its underlying basis and function in ovarian cancer, as well as its potential applications in the treatment of ovarian cancer. Ivyspring International Publisher 2022-10-17 /pmc/articles/PMC9682507/ /pubmed/36438923 http://dx.doi.org/10.7150/ijms.76480 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhao, Hongjiang
Xu, Yuan
Shang, Hongkai
Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title_full Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title_fullStr Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title_full_unstemmed Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title_short Ferroptosis: A New Promising Target for Ovarian Cancer Therapy
title_sort ferroptosis: a new promising target for ovarian cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682507/
https://www.ncbi.nlm.nih.gov/pubmed/36438923
http://dx.doi.org/10.7150/ijms.76480
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