Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages

Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular determinant of metabolic adaptions in pro-inflammatory macrophages. Post-translational modifications play a central role...

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Detalles Bibliográficos
Autores principales: Wang, Jizhuang, Yang, Peilang, Yu, Tianyi, Gao, Min, Liu, Dan, Zhang, Jie, Lu, Chenghao, Chen, Xuelian, Zhang, Xiong, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682528/
https://www.ncbi.nlm.nih.gov/pubmed/36439872
http://dx.doi.org/10.7150/ijbs.75434

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