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Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment
The human gut microbiota is associated with the development and progression of colorectal cancer, and manipulation of the gut microbiota is a novel strategy for the prevention and treatment of colorectal cancer. Some bacteria have antitumor activity against colorectal cancer, where specific bacteria...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682563/ https://www.ncbi.nlm.nih.gov/pubmed/36438840 http://dx.doi.org/10.3389/fphar.2022.1051330 |
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author | Xia, Cong Cai, Yantao Ren, Shuangyi Xia, Chenglai |
author_facet | Xia, Cong Cai, Yantao Ren, Shuangyi Xia, Chenglai |
author_sort | Xia, Cong |
collection | PubMed |
description | The human gut microbiota is associated with the development and progression of colorectal cancer, and manipulation of the gut microbiota is a novel strategy for the prevention and treatment of colorectal cancer. Some bacteria have antitumor activity against colorectal cancer, where specific bacteria can improve the tumor microenvironment, activate immune cells including dendritic cells, helper T cells, natural killer cells, and cytotoxic T cells, and upregulate the secretion of pro-tumor immune cytokines such as interleukin-2 and interferon. In this paper, we summarize some bacteria with potential benefits in colorectal cancer and describe their roles in the tumor microenvironment, demonstrate the application of gut microbes in combination with immunosuppressive agents, and provide suggestions for further experimental studies and clinical practice applications. |
format | Online Article Text |
id | pubmed-9682563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96825632022-11-24 Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment Xia, Cong Cai, Yantao Ren, Shuangyi Xia, Chenglai Front Pharmacol Pharmacology The human gut microbiota is associated with the development and progression of colorectal cancer, and manipulation of the gut microbiota is a novel strategy for the prevention and treatment of colorectal cancer. Some bacteria have antitumor activity against colorectal cancer, where specific bacteria can improve the tumor microenvironment, activate immune cells including dendritic cells, helper T cells, natural killer cells, and cytotoxic T cells, and upregulate the secretion of pro-tumor immune cytokines such as interleukin-2 and interferon. In this paper, we summarize some bacteria with potential benefits in colorectal cancer and describe their roles in the tumor microenvironment, demonstrate the application of gut microbes in combination with immunosuppressive agents, and provide suggestions for further experimental studies and clinical practice applications. Frontiers Media S.A. 2022-11-08 /pmc/articles/PMC9682563/ /pubmed/36438840 http://dx.doi.org/10.3389/fphar.2022.1051330 Text en Copyright © 2022 Xia, Cai, Ren and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Xia, Cong Cai, Yantao Ren, Shuangyi Xia, Chenglai Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title | Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title_full | Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title_fullStr | Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title_full_unstemmed | Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title_short | Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment |
title_sort | role of microbes in colorectal cancer therapy: cross-talk between the microbiome and tumor microenvironment |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682563/ https://www.ncbi.nlm.nih.gov/pubmed/36438840 http://dx.doi.org/10.3389/fphar.2022.1051330 |
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