Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

BACKGROUND: Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellular debris upon myelin damage or demyelination, a common p...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Na, Wang, Minghui, Jeevaratnam, Suren, Rosenberg, Cassandra, Ikezu, Tadafumi C., Shue, Francis, Doss, Sydney V., Alnobani, Alla, Martens, Yuka A., Wren, Melissa, Asmann, Yan W., Zhang, Bin, Bu, Guojun, Liu, Chia-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682675/
https://www.ncbi.nlm.nih.gov/pubmed/36419137
http://dx.doi.org/10.1186/s13024-022-00577-1

Ejemplares similares

Ejemplares similares