Cargando…

Steroid treatment as anti-inflammatory and neuroprotective agent following out-of-hospital cardiac arrest: a randomized clinical trial

BACKGROUND: Patients resuscitated from out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality risk and often develop post-cardiac arrest syndrome (PCAS) involving systemic inflammation. The severity of the inflammatory response is associated with adverse outcome, with anoxic irrev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Obling, Laust Emil Roelsgaard, Beske, Rasmus Paulin, Wiberg, Sebastian, Folke, Fredrik, Moeller, Jacob Eifer, Kjaergaard, Jesper, Hassager, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682762/ https://www.ncbi.nlm.nih.gov/pubmed/36414975 http://dx.doi.org/10.1186/s13063-022-06838-0

Ejemplares similares

Quantitative pupillometry for neuroprognostication in comatose post-cardiac arrest patients: A protocol for a predefined sub-study of the Blood pressure and Oxygenations Targets after Out-of-Hospital Cardiac Arrest (BOX)-trial
por: Nyholm, Benjamin, et al.
Publicado: (2023)

Specific thresholds of quantitative pupillometry parameters predict unfavorable outcome in comatose survivors early after cardiac arrest
por: Nyholm, Benjamin, et al.
Publicado: (2023)

Treatment Effects of Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response After Out-of-Hospital Cardiac Arrest (The IMICA Trial): A Double-Blinded, Placebo-Controlled, Single-Center, Randomized, Clinical Trial
por: Meyer, Martin Abild Stengaard, et al.
Publicado: (2021)

Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest
por: Grand, Johannes, et al.
Publicado: (2023)

GLP-1 analogues for neuroprotection after out-of-hospital cardiac arrest: study protocol for a randomized controlled trial
por: Wiberg, Sebastian, et al.
Publicado: (2016)

Predicting poor neurological outcomes following out-of-hospital cardiac arrest using neuron-specific enolase and neurofilament light chain in patients with and without haemolysis
por: Abdi Isse, Yusuf, et al.
Publicado: (2023)

Inverse Association Between Bystander Use of Audiovisual Feedback From an Automated External Defibrillator and Return of Spontaneous Circulation
por: Obling, Laust, et al.
Publicado: (2022)

Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response after Out-of-Hospital Cardiac Arrest (IMICA): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial
por: Meyer, Martin A. S., et al.
Publicado: (2020)

Superior reproducibility and repeatability in automated quantitative pupillometry compared to standard manual assessment, and quantitative pupillary response parameters present high reliability in critically ill cardiac patients
por: Nyholm, Benjamin, et al.
Publicado: (2022)

Hemodynamic and metabolic recovery in acute myocardial infarction-related cardiogenic shock is more rapid among patients presenting with out-of-hospital cardiac arrest
por: Josiassen, Jakob, et al.
Publicado: (2020)

The Value of the Biomarkers Neuron-Specific Enolase and S100 Calcium-Binding Protein for Prediction of Mortality in Children Resuscitated After Cardiac Arrest
por: Bangshøj, Johanne, et al.
Publicado: (2022)

Selection of patients for mechanical circulatory support for refractory out-of-hospital cardiac arrest
por: Linde, Louise, et al.
Publicado: (2023)

Impella to Treat Acute Myocardial Infarct-Related Cardiogenic Shock
por: Møller, Jacob Eifer, et al.
Publicado: (2022)

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with ST-Elevation Myocardial Infarction and Its Association with Acute Kidney Injury and Mortality
por: Højagergaard, Mathias Alexander, et al.
Publicado: (2023)

Community intervention to improve defibrillation before ambulance arrival in residential neighbourhoods with a high risk of out-of-hospital cardiac arrest: study protocol of a cluster-randomised trial (the CARAMBA trial)
por: Juul Grabmayr, Anne, et al.
Publicado: (2023)

Hemodynamic evaluation by serial right heart catheterizations after cardiac arrest; protocol of a sub-study from the Blood Pressure and Oxygenation Targets after Out-of-Hospital Cardiac Arrest-trial (BOX)
por: Grand, Johannes, et al.
Publicado: (2021)

Accidental hypothermia in Denmark: A nationwide cohort study of incidence and outcomes
por: Wiberg, Sebastian, et al.
Publicado: (2021)

Refractory out-of-hospital cardiac arrest with ongoing cardiopulmonary resuscitation at hospital arrival – survival and neurological outcome without extracorporeal cardiopulmonary resuscitation
por: Gregers, Emilie, et al.
Publicado: (2018)

Corrigendum to “Hemodynamic evaluation by serial right heart catheterizations after cardiac arrest; protocol of a sub-study from the Blood Pressure and Oxygenation Targets after Out-of-Hospital Cardiac Arrest-trial (BOX)” [Resuscitation Plus 8 (2021) 100188]
por: Grand, Johannes, et al.
Publicado: (2022)

Citizen Responder Activation in Out‐of‐Hospital Cardiac Arrest by Time of Day and Day of Week
por: Mottlau, Katarina Høgh, et al.
Publicado: (2022)

Volunteer responder provision of support to relatives of out-of-hospital cardiac arrest patients: a qualitative study
por: Kragh, Astrid Rolin, et al.
Publicado: (2023)

Sympathoadrenal Activation and Endothelial Damage Are Inter Correlated and Predict Increased Mortality in Patients Resuscitated after Out-Of-Hospital Cardiac Arrest. A Post Hoc Sub-Study of Patients from the TTM-Trial
por: Johansson, Pär I., et al.
Publicado: (2015)

Collaboration between emergency physicians and citizen responders in out-of-hospital cardiac arrest resuscitation
por: Jellestad, Anne-Sofie Linde, et al.
Publicado: (2021)

The negotiation of the sick role: general practitioners’ classification of patients with medically unexplained symptoms
por: Mik-Meyer, Nanna, et al.
Publicado: (2012)

Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study
por: Mørk, Sivagowry Rasalingam, et al.
Publicado: (2021)

Efficacy of a glucagon-like peptide-1 agonist and restrictive versus liberal oxygen supply in patients undergoing coronary artery bypass grafting or aortic valve replacement: study protocol for a 2-by-2 factorial designed, randomised clinical trial
por: Wiberg, Sebastian, et al.
Publicado: (2021)

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest
por: Ashton, Nicholas J., et al.
Publicado: (2023)

Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest
por: Heimburg, Katarina, et al.
Publicado: (2022)

Predictors of right ventricular function as measured by tricuspid annular plane systolic excursion in heart failure
por: Kjaergaard, Jesper, et al.
Publicado: (2009)

A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest
por: Jonesco, Ditte S., et al.
Publicado: (2019)

Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol
por: Wagner, Mette Kirstine, et al.
Publicado: (2020)

Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
por: Andersson, Peder, et al.
Publicado: (2021)

Endothelial Dysfunction in Resuscitated Cardiac Arrest (ENDO-RCA): safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac arrest syndrome patients: study protocol for a randomized controlled trial
por: Meyer, Anna Sina P., et al.
Publicado: (2016)

Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial
por: Nielsen, Niklas, et al.
Publicado: (2013)

Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: an explorative analysis of a randomized trial
por: Ebner, Florian, et al.
Publicado: (2019)

Risk of out‐of‐hospital cardiac arrest in patients with epilepsy and users of antiepileptic drugs
por: Eroglu, Talip E., et al.
Publicado: (2022)

Design paper of the “Blood pressure targets in post-resuscitation care and bedside monitoring of cerebral energy state: a randomized clinical trial”
por: Mölström, Simon, et al.
Publicado: (2019)

Ethnic disparities in out-of-hospital cardiac arrest: A population-based cohort study among adult Danish immigrants
por: Garcia, Rodrigue, et al.
Publicado: (2022)

Out-of-Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark
por: Wichmann, Janine, et al.
Publicado: (2013)

Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest – A TTM-Trial Substudy
por: Wiberg, Sebastian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_efan8lcq9s75eir3a6pg8v126j