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Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental and computational studies, focused on the human enzyme PTP1B and the PTP from Yersinia pestis, Y...

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Detalles Bibliográficos
Autores principales:	Shen, Ruidan, Crean, Rory M., Olsen, Keith J., Corbella, Marina, Calixto, Ana R., Richan, Teisha, Brandão, Tiago A. S., Berry, Ryan D., Tolman, Alex, Loria, J. Patrick, Johnson, Sean J., Kamerlin, Shina C. L., Hengge, Alvan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682893/ https://www.ncbi.nlm.nih.gov/pubmed/36507179 http://dx.doi.org/10.1039/d2sc04135a

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