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Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer

Sulfoximines are synthetically important scaffolds and serve important roles in drug discovery. Currently, there is no solution to decarboxylative sulfoximination of benzoic acids; although thoroughly investigated, limited substrate scope and harsh reaction conditions still hold back traditional the...

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Detalles Bibliográficos
Autores principales: Xu, Peng, Su, Wanqi, Ritter, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682917/
https://www.ncbi.nlm.nih.gov/pubmed/36507153
http://dx.doi.org/10.1039/d2sc05442f
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author Xu, Peng
Su, Wanqi
Ritter, Tobias
author_facet Xu, Peng
Su, Wanqi
Ritter, Tobias
author_sort Xu, Peng
collection PubMed
description Sulfoximines are synthetically important scaffolds and serve important roles in drug discovery. Currently, there is no solution to decarboxylative sulfoximination of benzoic acids; although thoroughly investigated, limited substrate scope and harsh reaction conditions still hold back traditional thermal aromatic decarboxylative functionalization. Herein, we realize the first decarboxylative sulfoximination of benzoic acids via photo-induced ligand to copper charge transfer (copper-LMCT)-enabled decarboxylative carbometalation. The transformation proceeds under mild reaction conditions, has a broad substrate scope, and can be applied to late-stage functionalization of complex small molecules.
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spelling pubmed-96829172022-12-08 Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer Xu, Peng Su, Wanqi Ritter, Tobias Chem Sci Chemistry Sulfoximines are synthetically important scaffolds and serve important roles in drug discovery. Currently, there is no solution to decarboxylative sulfoximination of benzoic acids; although thoroughly investigated, limited substrate scope and harsh reaction conditions still hold back traditional thermal aromatic decarboxylative functionalization. Herein, we realize the first decarboxylative sulfoximination of benzoic acids via photo-induced ligand to copper charge transfer (copper-LMCT)-enabled decarboxylative carbometalation. The transformation proceeds under mild reaction conditions, has a broad substrate scope, and can be applied to late-stage functionalization of complex small molecules. The Royal Society of Chemistry 2022-11-14 /pmc/articles/PMC9682917/ /pubmed/36507153 http://dx.doi.org/10.1039/d2sc05442f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Xu, Peng
Su, Wanqi
Ritter, Tobias
Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title_full Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title_fullStr Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title_full_unstemmed Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title_short Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
title_sort decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682917/
https://www.ncbi.nlm.nih.gov/pubmed/36507153
http://dx.doi.org/10.1039/d2sc05442f
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