Cargando…

Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinological disease affecting women in the reproductive age. Non-alcoholic fatty pancreas disease (NAFPD) can promote many aspects of pancreatic dysfunction. The present study aimed to determine the prevalence of NAFPD and to ident...

Descripción completa

Detalles Bibliográficos
Autores principales: Osman, Mustafa A A, Alkhouly, Mohamed, Elmohaseb, Ghada F, Nassef, Eman Mostafa, Mohamed, Ibrahim Ghonim Ramadan, El mancy, Ismail Mohamed, Sabry, Seham, Abdulrehim, Marwa M, Eliwa, Ahmed, Eisa, Yasmine H, Abdel-Ghany, Ahmed, Abdelghani, Yasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682932/
https://www.ncbi.nlm.nih.gov/pubmed/36438020
http://dx.doi.org/10.2147/IJGM.S384073
_version_ 1784834966622830592
author Osman, Mustafa A A
Alkhouly, Mohamed
Elmohaseb, Ghada F
Nassef, Eman Mostafa
Mohamed, Ibrahim Ghonim Ramadan
El mancy, Ismail Mohamed
Sabry, Seham
Abdulrehim, Marwa M
Eliwa, Ahmed
Eisa, Yasmine H
Abdel-Ghany, Ahmed
Abdelghani, Yasser
author_facet Osman, Mustafa A A
Alkhouly, Mohamed
Elmohaseb, Ghada F
Nassef, Eman Mostafa
Mohamed, Ibrahim Ghonim Ramadan
El mancy, Ismail Mohamed
Sabry, Seham
Abdulrehim, Marwa M
Eliwa, Ahmed
Eisa, Yasmine H
Abdel-Ghany, Ahmed
Abdelghani, Yasser
author_sort Osman, Mustafa A A
collection PubMed
description BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinological disease affecting women in the reproductive age. Non-alcoholic fatty pancreas disease (NAFPD) can promote many aspects of pancreatic dysfunction. The present study aimed to determine the prevalence of NAFPD and to identify its association with clinical and biochemical parameters in PCOS patients. METHODS: The present study included 150 patients with PCOS and 150 age-matched healthy controls. All patients were submitted to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting and postprandial blood glucose, lipid profile, liver function tests, serum prolactin and total testosterone. Fatty pancreas was diagnosed using abdominal ultrasound. RESULTS: Among PCOS women, NAFPD was diagnosed in 57 women (38.0%) in contrast to 18 women (12.0%) in the control group (p < 0.001). Patients with NAFPD were significantly older [median (IQR): 38.0 (35.0–43.0) versus 29.0 (25.5–33.0) years, p = 0.001] with higher BMI [median (IQR): 31.5 (29.1–34.7) versus 30.4 (28.6–32.4) kg/m(2), 0.042]. Moreover, they had significantly higher frequency of metabolic syndrome (84.2% versus 54.8%, p = 0.001), insulin resistance (68.4% versus 26.9%, p < 0.001) and severe NAFLD (22.8% versus 2.2%, p < 0.001). NAFPD patients had significantly lower sex hormone binding globulin (SHBG) [median (IQR): 36.0 (30.8–40.7) versus 38.1 (35.15–42.7), p = 0.002] and significantly higher free androgen index (FAI) [median (IQR): 4.08 (3.3–4.92) versus 3.47 (3.12–4.05), p < 0.001]. CONCLUSION: NAFPD is prevalent PCOS. It is related to metabolic syndrome, insulin resistance, dyslipidemia and hyperandrogenism.
format Online
Article
Text
id pubmed-9682932
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-96829322022-11-24 Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study Osman, Mustafa A A Alkhouly, Mohamed Elmohaseb, Ghada F Nassef, Eman Mostafa Mohamed, Ibrahim Ghonim Ramadan El mancy, Ismail Mohamed Sabry, Seham Abdulrehim, Marwa M Eliwa, Ahmed Eisa, Yasmine H Abdel-Ghany, Ahmed Abdelghani, Yasser Int J Gen Med Original Research BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinological disease affecting women in the reproductive age. Non-alcoholic fatty pancreas disease (NAFPD) can promote many aspects of pancreatic dysfunction. The present study aimed to determine the prevalence of NAFPD and to identify its association with clinical and biochemical parameters in PCOS patients. METHODS: The present study included 150 patients with PCOS and 150 age-matched healthy controls. All patients were submitted to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting and postprandial blood glucose, lipid profile, liver function tests, serum prolactin and total testosterone. Fatty pancreas was diagnosed using abdominal ultrasound. RESULTS: Among PCOS women, NAFPD was diagnosed in 57 women (38.0%) in contrast to 18 women (12.0%) in the control group (p < 0.001). Patients with NAFPD were significantly older [median (IQR): 38.0 (35.0–43.0) versus 29.0 (25.5–33.0) years, p = 0.001] with higher BMI [median (IQR): 31.5 (29.1–34.7) versus 30.4 (28.6–32.4) kg/m(2), 0.042]. Moreover, they had significantly higher frequency of metabolic syndrome (84.2% versus 54.8%, p = 0.001), insulin resistance (68.4% versus 26.9%, p < 0.001) and severe NAFLD (22.8% versus 2.2%, p < 0.001). NAFPD patients had significantly lower sex hormone binding globulin (SHBG) [median (IQR): 36.0 (30.8–40.7) versus 38.1 (35.15–42.7), p = 0.002] and significantly higher free androgen index (FAI) [median (IQR): 4.08 (3.3–4.92) versus 3.47 (3.12–4.05), p < 0.001]. CONCLUSION: NAFPD is prevalent PCOS. It is related to metabolic syndrome, insulin resistance, dyslipidemia and hyperandrogenism. Dove 2022-11-19 /pmc/articles/PMC9682932/ /pubmed/36438020 http://dx.doi.org/10.2147/IJGM.S384073 Text en © 2022 Osman et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Osman, Mustafa A A
Alkhouly, Mohamed
Elmohaseb, Ghada F
Nassef, Eman Mostafa
Mohamed, Ibrahim Ghonim Ramadan
El mancy, Ismail Mohamed
Sabry, Seham
Abdulrehim, Marwa M
Eliwa, Ahmed
Eisa, Yasmine H
Abdel-Ghany, Ahmed
Abdelghani, Yasser
Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title_full Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title_fullStr Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title_full_unstemmed Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title_short Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
title_sort relation between non-alcoholic fatty pancreas and clinical and biochemical parameters in women with polycystic ovary syndrome: a multi-centric study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682932/
https://www.ncbi.nlm.nih.gov/pubmed/36438020
http://dx.doi.org/10.2147/IJGM.S384073
work_keys_str_mv AT osmanmustafaaa relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT alkhoulymohamed relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT elmohasebghadaf relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT nassefemanmostafa relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT mohamedibrahimghonimramadan relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT elmancyismailmohamed relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT sabryseham relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT abdulrehimmarwam relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT eliwaahmed relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT eisayasmineh relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT abdelghanyahmed relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy
AT abdelghaniyasser relationbetweennonalcoholicfattypancreasandclinicalandbiochemicalparametersinwomenwithpolycysticovarysyndromeamulticentricstudy