pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells

The evolutionarily conserved, structural HSV-1 tegument protein pUL36 is essential for both virus entry and assembly. While its N-terminal deubiquitinase (DUB) activity is dispensable for infection in cell culture, it is required for efficient virus spread in vivo, as it acts as a potent viral immun...

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Detalles Bibliográficos
Autores principales: Mohnke, Jonas, Stark, Irmgard, Fischer, Mara, Fischer, Patrick M., Schlosser, Andreas, Grothey, Arnhild, O’Hare, Peter, Sodeik, Beate, Erhard, Florian, Dölken, Lars, Hennig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683058/
https://www.ncbi.nlm.nih.gov/pubmed/36314822
http://dx.doi.org/10.1128/jvi.00963-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683058/
https://www.ncbi.nlm.nih.gov/pubmed/36314822
http://dx.doi.org/10.1128/jvi.00963-22

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