Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683112/ https://www.ncbi.nlm.nih.gov/pubmed/34852265 http://dx.doi.org/10.1016/j.bjane.2021.09.021 |
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author | Bisinotto, Flora Margarida Barra Martins, Laura Bisinotto de Camargos, Giovanini Pires Bianco, Marcelo de Paula |
author_facet | Bisinotto, Flora Margarida Barra Martins, Laura Bisinotto de Camargos, Giovanini Pires Bianco, Marcelo de Paula |
author_sort | Bisinotto, Flora Margarida Barra |
collection | PubMed |
description | Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We describe the case of a patient with GT and platelet refractoriness, who was submitted to radical prostatectomy and dental extraction. The perioperative treatment with apheresis platelet concentrate and activated recombinant factor seven allowed the procedures to be performed uneventfully. We discuss the complexity of the case and the treatment option. |
format | Online Article Text |
id | pubmed-9683112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96831122022-11-24 Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report Bisinotto, Flora Margarida Barra Martins, Laura Bisinotto de Camargos, Giovanini Pires Bianco, Marcelo de Paula Braz J Anesthesiol Case Report Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We describe the case of a patient with GT and platelet refractoriness, who was submitted to radical prostatectomy and dental extraction. The perioperative treatment with apheresis platelet concentrate and activated recombinant factor seven allowed the procedures to be performed uneventfully. We discuss the complexity of the case and the treatment option. Elsevier 2021-11-28 /pmc/articles/PMC9683112/ /pubmed/34852265 http://dx.doi.org/10.1016/j.bjane.2021.09.021 Text en © 2021 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Bisinotto, Flora Margarida Barra Martins, Laura Bisinotto de Camargos, Giovanini Pires Bianco, Marcelo de Paula Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title | Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title_full | Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title_fullStr | Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title_full_unstemmed | Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title_short | Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
title_sort | perioperative administration of recombinant activated factor vii in a glanzmannʼs thrombasthenia patient with platelet refractoriness: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683112/ https://www.ncbi.nlm.nih.gov/pubmed/34852265 http://dx.doi.org/10.1016/j.bjane.2021.09.021 |
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