Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report

Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We...

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Autores principales: Bisinotto, Flora Margarida Barra, Martins, Laura Bisinotto, de Camargos, Giovanini Pires, Bianco, Marcelo de Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683112/
https://www.ncbi.nlm.nih.gov/pubmed/34852265
http://dx.doi.org/10.1016/j.bjane.2021.09.021
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author Bisinotto, Flora Margarida Barra
Martins, Laura Bisinotto
de Camargos, Giovanini Pires
Bianco, Marcelo de Paula
author_facet Bisinotto, Flora Margarida Barra
Martins, Laura Bisinotto
de Camargos, Giovanini Pires
Bianco, Marcelo de Paula
author_sort Bisinotto, Flora Margarida Barra
collection PubMed
description Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We describe the case of a patient with GT and platelet refractoriness, who was submitted to radical prostatectomy and dental extraction. The perioperative treatment with apheresis platelet concentrate and activated recombinant factor seven allowed the procedures to be performed uneventfully. We discuss the complexity of the case and the treatment option.
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spelling pubmed-96831122022-11-24 Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report Bisinotto, Flora Margarida Barra Martins, Laura Bisinotto de Camargos, Giovanini Pires Bianco, Marcelo de Paula Braz J Anesthesiol Case Report Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control. Platelet transfusion is the main treatment, albeit refractoriness can occur. We describe the case of a patient with GT and platelet refractoriness, who was submitted to radical prostatectomy and dental extraction. The perioperative treatment with apheresis platelet concentrate and activated recombinant factor seven allowed the procedures to be performed uneventfully. We discuss the complexity of the case and the treatment option. Elsevier 2021-11-28 /pmc/articles/PMC9683112/ /pubmed/34852265 http://dx.doi.org/10.1016/j.bjane.2021.09.021 Text en © 2021 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Bisinotto, Flora Margarida Barra
Martins, Laura Bisinotto
de Camargos, Giovanini Pires
Bianco, Marcelo de Paula
Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title_full Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title_fullStr Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title_full_unstemmed Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title_short Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
title_sort perioperative administration of recombinant activated factor vii in a glanzmannʼs thrombasthenia patient with platelet refractoriness: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683112/
https://www.ncbi.nlm.nih.gov/pubmed/34852265
http://dx.doi.org/10.1016/j.bjane.2021.09.021
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