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Cervical cancer survival times in Africa

OBJECTIVE: Accessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival...

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Autores principales: Drokow, Emmanuel Kwateng, Fangninou, Fangnon Firmin, Effah, Clement Yaw, Agboyibor, Clement, Zhang, Yunfeng, Arboh, Francisca, Deku, Marie-Anne, Xinyin, Wu, Wang, Yue, Sun, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683338/
https://www.ncbi.nlm.nih.gov/pubmed/36438301
http://dx.doi.org/10.3389/fpubh.2022.981383
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author Drokow, Emmanuel Kwateng
Fangninou, Fangnon Firmin
Effah, Clement Yaw
Agboyibor, Clement
Zhang, Yunfeng
Arboh, Francisca
Deku, Marie-Anne
Xinyin, Wu
Wang, Yue
Sun, Kai
author_facet Drokow, Emmanuel Kwateng
Fangninou, Fangnon Firmin
Effah, Clement Yaw
Agboyibor, Clement
Zhang, Yunfeng
Arboh, Francisca
Deku, Marie-Anne
Xinyin, Wu
Wang, Yue
Sun, Kai
author_sort Drokow, Emmanuel Kwateng
collection PubMed
description OBJECTIVE: Accessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age. METHODS AND MATERIALS: Major electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). RESULTS: A total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%). CONCLUSION: To enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required.
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spelling pubmed-96833382022-11-24 Cervical cancer survival times in Africa Drokow, Emmanuel Kwateng Fangninou, Fangnon Firmin Effah, Clement Yaw Agboyibor, Clement Zhang, Yunfeng Arboh, Francisca Deku, Marie-Anne Xinyin, Wu Wang, Yue Sun, Kai Front Public Health Public Health OBJECTIVE: Accessibility to quality healthcare, histopathology of tumor, tumor stage and geographical location influence survival rates. Comprehending the bases of these differences in cervical cancer survival rate, as well as the variables linked to poor prognosis, is critical to improving survival. We aimed to perform the first thorough meta-analysis and systematic review of cervical cancer survival times in Africa based on race, histopathology, geographical location and age. METHODS AND MATERIALS: Major electronic databases were searched for articles published about cervical cancer survival rate in Africa. The eligible studies involved studies which reported 1-year, 3-year or 5-year overall survival (OS), disease-free survival (DFS) and/or locoregional recurrence (LRR) rate of cervical cancer patients living in Africa. Two reviewers independently chose the studies and evaluated the quality of the selected publications, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). We used random effects analysis to pooled the survival rate across studies and heterogeneity was explored via sub-group and meta-regression analyses. A leave-one-out sensitivity analysis was undertaken, as well as the reporting bias assessment. Our findings were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-P). RESULTS: A total of 16,122 women with cervical cancer were covered in the 45 articles (59 studies), with research sample sizes ranging from 22 to 1,059 (median = 187.5). The five-year overall survival (OS) rate was 40.9% (95% CI: 35.5–46.5%). The five-year OS rate ranged from 3.9% (95% CI: 1.9–8.0%) in Malawi to as high as 76.1% (95% CI: 66.3–83.7%) in Ghana. The five-year disease-free survival rate was 66.2% (95% CI: 44.2–82.8%) while the five-year locoregional rate survival was 57.0% (95% CI: 41.4–88.7%). CONCLUSION: To enhance cervical cancer survival, geographical and racial group health promotion measures, as well as prospective genetic investigations, are critically required. Frontiers Media S.A. 2022-11-09 /pmc/articles/PMC9683338/ /pubmed/36438301 http://dx.doi.org/10.3389/fpubh.2022.981383 Text en Copyright © 2022 Drokow, Fangninou, Effah, Agboyibor, Zhang, Arboh, Deku, Xinyin, Wang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Drokow, Emmanuel Kwateng
Fangninou, Fangnon Firmin
Effah, Clement Yaw
Agboyibor, Clement
Zhang, Yunfeng
Arboh, Francisca
Deku, Marie-Anne
Xinyin, Wu
Wang, Yue
Sun, Kai
Cervical cancer survival times in Africa
title Cervical cancer survival times in Africa
title_full Cervical cancer survival times in Africa
title_fullStr Cervical cancer survival times in Africa
title_full_unstemmed Cervical cancer survival times in Africa
title_short Cervical cancer survival times in Africa
title_sort cervical cancer survival times in africa
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683338/
https://www.ncbi.nlm.nih.gov/pubmed/36438301
http://dx.doi.org/10.3389/fpubh.2022.981383
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