The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) glycoprotein mutations. S receptor binding domain (RBD) comprises a free fatty acid (FFA)–binding pocket. FFA binding stabilizes a l...

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Detalles Bibliográficos
Autores principales: Toelzer, Christine, Gupta, Kapil, Yadav, Sathish K. N., Hodgson, Lorna, Williamson, Maia Kavanagh, Buzas, Dora, Borucu, Ufuk, Powers, Kyle, Stenner, Richard, Vasileiou, Kate, Garzoni, Frederic, Fitzgerald, Daniel, Payré, Christine, Gautam, Gunjan, Lambeau, Gérard, Davidson, Andrew D., Verkade, Paul, Frank, Martin, Berger, Imre, Schaffitzel, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683698/
https://www.ncbi.nlm.nih.gov/pubmed/36417532
http://dx.doi.org/10.1126/sciadv.adc9179

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