Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions

Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive se...

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Detalles Bibliográficos
Autores principales: Jacquet, Stéphanie, Culbertson, Michelle, Zhang, Chi, El Filali, Adil, De La Myre Mory, Clément, Pons, Jean-Baptiste, Filippi-Codaccioni, Ondine, Lauterbur, M. Elise, Ngoubangoye, Barthélémy, Duhayer, Jeanne, Verez, Clément, Park, Chorong, Dahoui, Clara, Carey, Clayton M., Brennan, Greg, Enard, David, Cimarelli, Andrea, Rothenburg, Stefan, Elde, Nels C., Pontier, Dominique, Etienne, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683710/
https://www.ncbi.nlm.nih.gov/pubmed/36417524
http://dx.doi.org/10.1126/sciadv.add7540

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