Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism

Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are deficient in both ACC isoforms in myeloid cells. ACC deficiency altered the lipidomic, transcriptomic, and bioenergetic profile of bone marr...

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Detalles Bibliográficos
Autores principales: Yeudall, Scott, Upchurch, Clint M., Seegren, Philip V., Pavelec, Caitlin M., Greulich, Jan, Lemke, Michael C., Harris, Thurl E., Desai, Bimal N., Hoehn, Kyle L., Leitinger, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683712/
https://www.ncbi.nlm.nih.gov/pubmed/36417534
http://dx.doi.org/10.1126/sciadv.abq1984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683712/
https://www.ncbi.nlm.nih.gov/pubmed/36417534
http://dx.doi.org/10.1126/sciadv.abq1984

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