Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

Mutations in the transcription factor Phox2b cause congenital central hypoventilation syndrome (CCHS). The syndrome is characterized by hypoventilation and inability to regulate breathing to maintain adequate O(2) and CO(2) levels. The mechanism by which CCHS impact respiratory control is incomplete...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferreira, Caroline B, Silva, Talita M, Silva, Phelipe E, Castro, Claudio L, Czeisler, Catherine, Otero, José J, Takakura, Ana C, Moreira, Thiago S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683783/
https://www.ncbi.nlm.nih.gov/pubmed/36394266
http://dx.doi.org/10.7554/eLife.73130

Ejemplares similares

Ejemplares similares