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Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature

Regarding the prognosis of cases with advanced-stage hepatocellular carcinoma (HCC), a recent clinical study showed that the immune checkpoint inhibitors atezolizumab plus bevacizumab have superior efficacy to sorafenib. However, only a few reports have focused on their effects on extrahepatic metas...

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Autores principales: Ishikawa, Natsuki, Kamimura, Kenya, Endo, Saori, Ishii, Soichi, Ogawa, Kazuya, Sakai, Norihiro, Abe, Hiroyuki, Ko, Masayoshi, Shibata, Osamu, Koseki, Youhei, Yokoyama, Junji, Sakamaki, Akira, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683801/
https://www.ncbi.nlm.nih.gov/pubmed/35431306
http://dx.doi.org/10.2169/internalmedicine.9341-22
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author Ishikawa, Natsuki
Kamimura, Kenya
Endo, Saori
Ishii, Soichi
Ogawa, Kazuya
Sakai, Norihiro
Abe, Hiroyuki
Ko, Masayoshi
Shibata, Osamu
Koseki, Youhei
Yokoyama, Junji
Sakamaki, Akira
Terai, Shuji
author_facet Ishikawa, Natsuki
Kamimura, Kenya
Endo, Saori
Ishii, Soichi
Ogawa, Kazuya
Sakai, Norihiro
Abe, Hiroyuki
Ko, Masayoshi
Shibata, Osamu
Koseki, Youhei
Yokoyama, Junji
Sakamaki, Akira
Terai, Shuji
author_sort Ishikawa, Natsuki
collection PubMed
description Regarding the prognosis of cases with advanced-stage hepatocellular carcinoma (HCC), a recent clinical study showed that the immune checkpoint inhibitors atezolizumab plus bevacizumab have superior efficacy to sorafenib. However, only a few reports have focused on their effects on extrahepatic metastases. We herein report a case of HCC in a 59-year-old man with intrahepatic lesions treated successfully by hepatic arterial chemoembolization, radiotherapy, and sorafenib; the extrahepatic lesion in the adrenal gland was treated by atezolizumab plus bevacizumab. The patient showed a tumor-free condition for one year. We have summarized the clinical course and reviewed the literature to underscore the efficacy of atezolizumab plus bevacizumab for treating extrahepatic lesions of HCC.
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spelling pubmed-96838012022-12-02 Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature Ishikawa, Natsuki Kamimura, Kenya Endo, Saori Ishii, Soichi Ogawa, Kazuya Sakai, Norihiro Abe, Hiroyuki Ko, Masayoshi Shibata, Osamu Koseki, Youhei Yokoyama, Junji Sakamaki, Akira Terai, Shuji Intern Med Case Report Regarding the prognosis of cases with advanced-stage hepatocellular carcinoma (HCC), a recent clinical study showed that the immune checkpoint inhibitors atezolizumab plus bevacizumab have superior efficacy to sorafenib. However, only a few reports have focused on their effects on extrahepatic metastases. We herein report a case of HCC in a 59-year-old man with intrahepatic lesions treated successfully by hepatic arterial chemoembolization, radiotherapy, and sorafenib; the extrahepatic lesion in the adrenal gland was treated by atezolizumab plus bevacizumab. The patient showed a tumor-free condition for one year. We have summarized the clinical course and reviewed the literature to underscore the efficacy of atezolizumab plus bevacizumab for treating extrahepatic lesions of HCC. The Japanese Society of Internal Medicine 2022-04-16 2022-11-01 /pmc/articles/PMC9683801/ /pubmed/35431306 http://dx.doi.org/10.2169/internalmedicine.9341-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishikawa, Natsuki
Kamimura, Kenya
Endo, Saori
Ishii, Soichi
Ogawa, Kazuya
Sakai, Norihiro
Abe, Hiroyuki
Ko, Masayoshi
Shibata, Osamu
Koseki, Youhei
Yokoyama, Junji
Sakamaki, Akira
Terai, Shuji
Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title_full Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title_fullStr Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title_full_unstemmed Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title_short Effects of Atezolizumab and Bevacizumab on Adrenal Gland Metastasis of Hepatocellular Carcinoma: A Case Report and Review of Literature
title_sort effects of atezolizumab and bevacizumab on adrenal gland metastasis of hepatocellular carcinoma: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683801/
https://www.ncbi.nlm.nih.gov/pubmed/35431306
http://dx.doi.org/10.2169/internalmedicine.9341-22
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